Molecular therapy for the lost pancreatic β-cells in Diabetic patients: Valproic acid promotes an insulin-sensitized state via up-regulation of its target gene Lin-28, 23/March/2017, 8.17 pm

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What we say

Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy for the lost pancreatic β-cells in Diabetic patients: Valproic acid promotes an insulin-sensitized state via up-regulation of  its target gene Lin-28

price-300[easy_payment currency=”USD”]


From Significance of the study to Public health relevance

Given that: (1) more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) diabetic disease results in a number of health complications, including diabetic cardiomyopathy (DCM), diabetic nephropathy, diabetic retinopathy, and diabetic neuropathy; (3) one third of people with diabetes suffer from diabetic kidney disease (DKD); and one third of them will develop kidney failure; (4) Diabetes is going to be one of the top 10 causes of death by 2030; (5) the life-long painful injection/drug treatment is required to treat DM; (6) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find: (i) a way to induce regeneration of adult ß-cells that were lost in DM; (ii) a cheaper alternative to the existing expensive weight-loss drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, diabetes.


From Research findings to Therapeutic opportunity:

This study suggests, for the first time, that Valproic acid, by increasing the expression of its target geneit may (1) increase the expression of IGF1R, INSR, and IRS2; (2) enhance tissue repair; (3) promote regenerative capacity; (4) promote insulin sensitivity; (5) decrease myocardial infarct size; and (6) inhibit diabetic cardiomyopathy (DCM). 

Valproic acid induces Lin28 expression and promotes insulin sensitvity

Figure 1. Mechanistic insights into how Valproic acid functions as an anti-hyperglycemic/cardioprotective agent. Valproic acid, by increasing the expression of reprogramming protein Lin-28, IGFIR, INSR, and IRS2, it may promote insulin sensitivity and protect from diabetic cardiomyopathy.

Thus, pharmacological formulations encompassing Valproic acid or its analogues either alone or in combination with other drugs” may be used to treat DM and DCM.


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Amount: $ 300#

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Undisclosed mechanistic information: How does Valproic acid promote insulin-sensitized state?

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References

Web: http://genomediscovery.org or http://newbioideas.com/

CitationBoominathan L, Molecular therapy for the lost pancreatic β-cells in Diabetic patients: Valproic acid promotes an insulin-sensitized state via up-regulation of  its target gene Lin-28, 23/March/2017, 8.17 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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