Molecular therapy for the lost pancreatic β-cells in Diabetic patients: Valproic acid promotes an insulin-sensitized state via up-regulation of its target gene Lin-28, 23/March/2017, 8.17 pm

Natural product-derived therapy for Allergic rhinitis: Shikonin, found in Zicao/Lithospermum erythrorhizon, inhibits GM-CSF, Interleukin 13 receptor(IL-13)-Rα1, and eotaxin expression, among others, inhibits mucus production and alleviates allergic rhinitis via up regulation of its target gene, 22/March/2017, 11.37 pm
March 22, 2017
Natural product-derived therapy for Human cancers: Eriocitrin, one of the components of Lemons, increases the expression of mitochondrial protein LACTB, decreases levels of mitochondrial phosphatidylserine decarboxylase, alters mitochondrial lipid metabolism, and promotes differentiation of breast cancer cells via up-regulation of its target gene, 23/March/2017, 11.00 am
March 23, 2017
Show all

What we say

Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy for the lost pancreatic β-cells in Diabetic patients: Valproic acid promotes an insulin-sensitized state via up-regulation of  its target gene Lin-28

price-300[easy_payment currency=”USD”]

From Significance of the study to Public health relevance

Given that: (1) more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) diabetic disease results in a number of health complications, including diabetic cardiomyopathy (DCM), diabetic nephropathy, diabetic retinopathy, and diabetic neuropathy; (3) one third of people with diabetes suffer from diabetic kidney disease (DKD); and one third of them will develop kidney failure; (4) Diabetes is going to be one of the top 10 causes of death by 2030; (5) the life-long painful injection/drug treatment is required to treat DM; (6) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find: (i) a way to induce regeneration of adult ß-cells that were lost in DM; (ii) a cheaper alternative to the existing expensive weight-loss drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, diabetes.

From Research findings to Therapeutic opportunity:

This study suggests, for the first time, that Valproic acid, by increasing the expression of its target geneit may (1) increase the expression of IGF1R, INSR, and IRS2; (2) enhance tissue repair; (3) promote regenerative capacity; (4) promote insulin sensitivity; (5) decrease myocardial infarct size; and (6) inhibit diabetic cardiomyopathy (DCM). 

Valproic acid induces Lin28 expression and promotes insulin sensitvity

Figure 1. Mechanistic insights into how Valproic acid functions as an anti-hyperglycemic/cardioprotective agent. Valproic acid, by increasing the expression of reprogramming protein Lin-28, IGFIR, INSR, and IRS2, it may promote insulin sensitivity and protect from diabetic cardiomyopathy.

Thus, pharmacological formulations encompassing Valproic acid or its analogues either alone or in combination with other drugs” may be used to treat DM and DCM.

Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Amount: $ 300#

Terms & Conditions apply

Undisclosed mechanistic information: How does Valproic acid promote insulin-sensitized state?

# Research cooperation

For purchase details, you may reach us at


Web: or

CitationBoominathan L, Molecular therapy for the lost pancreatic β-cells in Diabetic patients: Valproic acid promotes an insulin-sensitized state via up-regulation of  its target gene Lin-28, 23/March/2017, 8.17 pm,  Genome-2-Bio-Medicine Discovery center (GBMD),

Courtesy: When you cite drop us a line at

Comments are closed.