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Introduction: What they say

A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was published in the online journal “Nature communications” by Prof. Jung YK, Pyo Jo and others. 


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMDreports that: Natural product-based Lifespan extension therapy:  Polydatin (PD), isolated from the root and rhizome of herb Polygonum cuspidatum,  activates autophagy and extends lifespan via up regulation of ATG5


From research findings to therapeutic opportunity

This study suggests, for the first time, that Polydatin (PD), by increasing the expression of its target gene ATG5, it may: (1) enhance autophagy, (2) promote leanness; (3) increase insulin sensitivity; (4) improve motor function; and (5) alleviate ageing features.

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Figure 1. Polydatin (PD), isolated from Polygonum cuspidatum,  functions as a longevity promoter by upregulating the expression of ATG5

Thus, pharmacological formulations encompassing Polydatin (PD) or its analogs either alone or in combination with other drugsmay be used to increase the life span of an individual.


Details of the research findings

Idea Proposed/Formulated byDr L Boominathan PhD

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References

Web: http://genomediscovery.org or newbioideas.com/

To citeBoominathan, Natural product-based Lifespan extension therapy:  Polydatin (PD), isolated from the root and rhizome of herb Polygonum cuspidatum,  activates autophagy and extends lifespan via up regulation of ATG5, 19/March/2017, 9.45 am

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