Research findings to Therapeutic opportunity:
A number of studies suggest that Hyperoside functions as an anticancer agent. However, the mechanism of action is far from clear.
This study suggests that Hyperoside, by decreasing the expression of its target genes, it may increase the expression of tumor suppressor BTG2 (B-cell translocation gene 2/NGF-inducible anti-proliferative protein PC3) (figs. 1-4).
Thereby, it may inhibit cell cycle progression, proliferation, migration, invasion and metastasis of cancer cells. Thus, pharmacological formulations encompassing “Hyperoside or its analogues either alone or in combination with other anticancer drugs” may be used to inhibit the progression of invasive tumors.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Undisclosed mechanistic information: How Hyperoside increases the expression of tumor suppressor BTG2
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Citation: Boominathan, L., Natural product-based therapy for Metastatic cancers: Hyperoside, isolated from Drosera rotundifolia, and Common self-heal, among others, increases the expression of BTG2 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 4/March/2017, 7.35 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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