Natural product-based therapy for Metastatic cancers: Hyperoside, isolated from Drosera rotundifolia, and Common self-heal, among others, increases the expression of KRIT1/CCM1 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 5/March/2017, 10.54 pm

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Research findings to Therapeutic opportunity: 

A number of studies suggest that Hyperoside functions as an anticancer agent. However, the mechanism of action is far from clear.

This study suggests that Hyperoside, by decreasing the expression of its target genes, it may increase the expression of tumor suppressor KRIT1/CCM1 (figs. 1-4).

Drosera rotundifolia க்கான பட முடிவு

Fig 1. Drosera rotundifolia. Hyperoside, isolated from Drosera rotundifolia, functions as an anti-metastasis agent

Prunella vulgaris க்கான பட முடிவு

Fig.2 Hyperoside, also found in Prunella vulgaris /Common self-heal, functions as an antimetastatic agent by increasing the expression of BTG2

Rumex acetosella க்கான பட முடிவு

Fig 3. Hyperoside is also found in Rumex acetosella

hyperoside க்கான பட முடிவு

Fig4. The chemical structure of Hyperoside

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Thereby, it may inhibit cell cycle progression, proliferation, migration, invasion and metastasis of cancer cells. Thus, pharmacological formulations encompassing “Hyperoside or its analogues either alone or in combination with other anticancer drugs” may be used to inhibit the progression of invasive tumors.


Details of the research findings

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Undisclosed mechanistic information: How Hyperoside increases the expression of tumor suppressor KRIT1/CCM1

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/


References

CitationBoominathan, L., Natural product-based therapy for Metastatic cancers: Hyperoside, isolated from Drosera rotundifolia, and Common self-heal, among others, increases the expression of KRIT1/CCM1 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 5/March/2017, 10.54 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com/

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