Natural product-derived PD-1 pathway blockade for Human cancer therapy: Salvianolic acid A, one of the main components of Salvia Miltiorrhiza Bge, decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 29/March/2017,4.53 am

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Introduction:What they say

A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK shows that “Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses.” This study was published in the 16 February 2016 issue of Immunity (one of the best journals in Immunology with an impact factor of 20+) by Prof Rudd CE, Taylor A and others.


What we say

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On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived PD-1 pathway blockade for Human cancer therapy: Salvianolic acid A, one of the main  components of Salvia Miltiorrhiza Bgedecreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene


What is known?

It has recently been shown that blocking PD-1 with antibodies one could make tumors shrink. This work, relating to Cancer immunotherapy, has been chosen as Science’s breakthrough of the year.


Research Findings

This study suggests a natural product-derived therapy for human cancers. Salvianolic acid Aby increasing the expression of its target gene, it may inhibit the activity of Glycogen synthase kinase 3-β (fig 1). Thereby, it may: (a) increase transcription factor T-bet expression; (b) inhibit co-inhibitory receptor PD-1 expression;  (c) increase CD8(+) cytotoxic T lymphocyte function; (d) augment anti-tumor activity; & (e) inhibit metastatic cancer progression (figs. 1-3)

Salvianolic acid A க்கான பட முடிவு

Fig 1 Salvianolic acid A serves as an anti-tumor immunity booster. Salvianolic acid A increases T-bet expression, inhibits PD-1 expression, and augments anti-tumor immunity

S. miltiorrhiza BGE க்கான பட முடிவு

Figure 2. S. miltiorrhiza BGE. Salvianolic acid A, found in S. miltiorrhiza BGE, augments anti-tumor immunity via down regulation of PD-1

S. miltiorrhiza BGE க்கான பட முடிவு

Figure 3. The roots of S. miltiorrhiza. Salvianolic acid A, isolated from the roots of S. miltiorrhiza, functions as an antitumor immunity booster.


Therapeutic opportunity

Thus, pharmacological formulations encompassing “Salvianolic acid A  or its analogues either alone or in combination with other drugs may be used to inhibit the progression of tumors.


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $50

Undisclosed information: How does  Salvianolic acid A suppress the expression of PD-1 to promote anti-tumor immunity?

# Research cooperation

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References:

Citation: Boominathan, L., Natural product-derived PD-1 pathway blockade for Human cancer therapy: Salvianolic acid A, one of the main  components of Salvia Miltiorrhiza Bgedecreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 29/March/2017,4.53 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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