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What we say

Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Salvianolic acid B, isolated from Salvia Miltiorrhiza Bunge, promotes an insulin-sensitized state via up-regulation of its target gene Lin-28, 28/March/2017, 10.08 am

price-300[easy_payment currency=”USD”]


From Significance of the study to Public health relevance

Given that: (1) more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) diabetic disease results in a number of health complications, including diabetic cardiomyopathy (DCM), diabetic nephropathy, diabetic retinopathy, and diabetic neuropathy; (3) one third of people with diabetes suffer from diabetic kidney disease (DKD); and one third of them will develop kidney failure; (4) Diabetes is going to be one of the top 10 causes of death by 2030; (5) the life-long painful injection/drug treatment is required to treat DM; (6) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find: (i) a way to induce regeneration of adult ß-cells that were lost in DM; (ii) a cheaper alternative to the existing expensive weight-loss drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, diabetes.


From Research findings to Therapeutic opportunity:

This study suggests, for the first time, that Salvianolic acid B, by increasing the expression of its target geneit may (1) increase the expression of IGF1R, INSR, and IRS2; (2) enhance tissue repair; (3) promote regenerative capacity; (4) promote insulin sensitivity; (5) decrease myocardial infarct size; and (6) inhibit diabetic cardiomyopathy (DCM). 

Salvianolic acid B induces Lin28 expression and promotes insulin sensitivity

Figure 1. Mechanistic insights into how Salvianolic acid B functions as an anti-hyperglycemic/cardioprotective agent. Salvianolic acid B, by increasing the expression of reprogramming protein Lin-28, IGFIR, INSR, and IRS2 among others, it may promote insulin sensitivity and protect from diabetic cardiomyopathy.


Thus,
 pharmacological formulations encompassing Salvianolic acid B or its analogues either alone or in combination with other drugs” may be used to treat DM and DCM.


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Amount: $ 300#

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Undisclosed mechanistic information: How does Salvianolic acid B promote insulin-sensitized state?

# Research cooperation

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References

Web: http://genomediscovery.org or http://newbioideas.com/

CitationBoominathan L, Natural product-derived therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Salvianolic acid B, isolated from Salvia Miltiorrhiza Bunge, promotes an insulin-sensitized state via up-regulation of its target gene Lin-28, 28/March/2017, 10.08 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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