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What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Shikonin, one of the major components of zicao (purple gromwell), promotes an insulin-sensitized state via up-regulation of  its target gene Lin-28

price-300[easy_payment currency=”USD”]


From Significance of the study to Public health relevance

Given that: (1) more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) diabetic disease results in a number of health complications, including diabetic cardiomyopathy (DCM), diabetic nephropathy, diabetic retinopathy, and diabetic neuropathy; (3) one third of people with diabetes suffer from diabetic kidney disease (DKD); and one third of them will develop kidney failure; (4) Diabetes is going to be one of the top 10 causes of death by 2030; (5) the life-long painful injection/drug treatment is required to treat DM; (6) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find: (i) a way to induce regeneration of adult ß-cells that were lost in DM; (ii) a cheaper alternative to the existing expensive weight-loss drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, diabetes.


From Research findings to Therapeutic opportunity:

This study suggests, for the first time, that Shikonin, by increasing the expression of its target geneit may (1) increase the expression of IGF1R, INSR, and IRS2; (2) enhance tissue repair; (3) promote youthful regenerative capacity; (4) promote insulin sensitivity; (5) decrease myocardial infarct size; and (6) inhibit diabetic cardiomyopathy (DCM). 

Shikonin induces Lin28 and promotes insulin sensitivity

Figure 1. Mechanistic insights into how Shikonin functions as an anti-hyperglycemic/cardioprotective agent. Shikonin, by increasing the expression of reprogramming protein Lin-28, IGFIR, INSR, and IRS2, it may promote insulin sensitivity and protect it from diabetic cardiomyopathy.

Thus, pharmacological formulations encompassing Shikonin or its analogues either alone or in combination with other drugs” may be used to treat DM and DCM.


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Amount: $ 300#

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does Shikonin promote insulin-sensitized state?

# Research cooperation


References

Web: http://genomediscovery.org or http://newbioideas.com/

CitationBoominathan L, Natural product-derived therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Shikonin, one of the major components of zicao (purple gromwell), promotes an insulin-sensitized state via up-regulation of  its target gene Lin-28, 9/March/2017, 8.01 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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