Natural product therapy for TIIDM and Metabolic defects: Ursolic acid, found in Mirabilis Jalapa, Ocimum sanctum and apple peels among others, increases IL-1ß expression, augments postprandial insulin secretion, decreases postprandial inflammation, reduces metabolic stress, improves glucose uptake, promotes glucose homeostasis and prevents progression to TIIDM via up regulation of its target gene, 15/March/2017, 11.53 pm

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Introduction: What they say

A study from the “Clinic of Endocrinology, Diabetes and Metabolism University Hospital Basel, Basel, Switzerland, and Department of Biomedicine, University of Basel, Basel, Switzerland” shows that “Postprandial macrophage-derived IL-1ß stimulates insulin, and both synergistically promote glucose disposal and inflammation.” This research paper was published in the 16 January 2017 issue of the journal “Nature immunology” [One of the best research journals in Immunology with an I.F of 20.004] by Prof. Marc Y Donath and Dror and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for TIIDM and Metabolic defects: Ursolic acid, found in Mirabilis Jalapa, Ocimum sanctum and apple peels among others, increases IL-1ß expression, augments postprandial insulin secretion, decreases postprandial inflammation, reduces metabolic stress, improves glucose uptake, promotes glucose homeostasis and prevents progression to TIIDM via up regulation of its target gene

price-quote[easy_payment currency=”USD”]


From significance of the study to public health relevance:

Given that: (1) more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) Diabetes is going to be one of the top 10 causes of death by 2030; (3) the life-long painful injection/drug treatment is required to treat DM; (3) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find: (i) a way to induce regeneration of adult ß-cells that were lost in DM; (ii) a cheaper alternative to the existing expensive weight-loss drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, diabetes.


What is known?

Prof. Mark Donath’s research team has recently shown that:(1) feeding induces peritoneal macrophages which in turn induces IL-1ß; (2) Insulin induces IL-1ß; (3) IL-1ß promotes postprandial insulin secretion; and (4) the lack of IL-1ß in mice decreases insulin levels, suggesting that increasing the expression of IL-1ß in diabetic and obese patients may alleviate metabolic defects and TIIDM.


From Research findings to Therapeutic opportunity:

This study suggests, for the first time, a natural product based therapy for metabolic defects and TIIDM. Ursolic acid, by increasing the expression of its target gene, it may increase the expression of IL-1ß. Thereby, it may: (1) increase postprandial insulin levels; (2) decrease postprandial blood glucose levels; (3) limit postprandial inflammation; (4) decrease metabolic stress; and (5) promote glucose homeostasis (Fig.1).

Ursolic acid incresases IL1b and promotes insulin secretion

Figure 1. Mechanistic insights into how Ursolic acid functions as an antidiabetic agent. Ursolic acid increases IL-1ß levels, augments insulin secretion and decreases postprandial glucose levels

Thus, pharmacological formulations encompassing “Ursolic acid or its analogues either alone or in combination with other drugs” may be used to control postprandial glucose levels within accepted limits (160 mg/dL); and treat TIIDM.


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does Ursolic acid increase the expression of IL-1ß to promote postprandial insulin secretion?

Amount: $500#

# Research cooperation

For purchase and payment details, you may reach us at info@genomediscovery.org


References:

Web: http://genomediscovery.org or http://newbioideas.com

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Citation: Boominathan, L., Natural product therapy for TIIDM and Metabolic defects: Ursolic acid, found in Mirabilis Jalapa, Ocimum sanctum and apple peels among others, increases IL-1ß expression, augments postprandial insulin secretion, decreases postprandial inflammation, reduces metabolic stress, improves glucose uptake, promotes glucose homeostasis and prevents progression to TIIDM via up regulation of its target gene, 15/March/2017, 11.53 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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