March

March 28, 2017

Natural product-derived therapy for enhancing the efficacy of tyrosine-kinase inhibitor (TKI) therapy in BCR-ABL-induced Human leukemia: Salvianolic acid A, one of the main components of Salvia Miltiorrhiza Bunge, decreases the expression of oncoproteins c-FOS, DUSP1 and BCR-ABL, inhibits TKI resistance, restores treatment responsiveness, increases therapeutic index of anticancer drugs, and cure CML and kinase-driven cancers via up-regulation of its target gene, 28/March/2017, 2.31 pm

Introduction: What they say: A study from the Division of Experimental Hematology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA; Division of Pathology, Cincinnati Children’s Hospital […]
March 28, 2017

Natural product-derived therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Salvianolic acid B, isolated from Salvia Miltiorrhiza Bunge, promotes an insulin-sensitized state via up-regulation of its target gene Lin-28, 28/March/2017, 10.08 am

What we say:  Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Salvianolic acid B, isolated […]
March 27, 2017

Natural product-derived PD-1 pathway blockade for Human cancer therapy: Methyl Jasmonate(MeJA), one of the main odour components of jasmine, decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 27/March/2017, 11.24 pm

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK […]
March 27, 2017

Natural product-derived therapy for Allergic rhinitis: Cucurbitacin E, found in Watermelons, inhibits GM-CSF, Interleukin 13 receptor(IL-13)-Rα1, and eotaxin expression, among others, inhibits mucus production and alleviates allergic rhinitis via up regulation of its target gene, 27/March/2017, 5.57 pm

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Allergic rhinitis: Cucurbitacin E, found in Watermelons,  inhibits GM-CSF, Interleukin 13 […]