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Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Vitamin-based therapy foRegenerating the lost pancreatic β-cells in Diabetic patients: Folic acid promotes an insulin-sensitized state via up-regulation of  its target gene Lin-28

price-300[easy_payment currency=”USD”]


From Significance of the study to Public health relevance: 

Given that: (1) more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) diabetic disease results in a number of health complications, including diabetic cardiomyopathy (DCM), diabetic nephropathy, diabetic retinopathy, and diabetic neuropathy; (3) one third of people with diabetes suffer from diabetic kidney disease (DKD); and one third of them will develop kidney failure; (4) Diabetes is going to be one of the top 10 causes of death by 2030; (5) the life-long painful injection/drug treatment is required to treat DM; (6) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find: (i) a way to induce regeneration of adult ß-cells that were lost in DM; (ii) a cheaper alternative to the existing expensive weight-loss drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, diabetes.


From Research findings to Therapeutic opportunity:

This study suggests, for the first time, that Folic acid, by increasing the expression of its target geneit may (1) increase the expression of IGF1R, INSR, and IRS2; (2) enhance tissue repair; (3) promote youthful regenerative capacity; (4) promote insulin sensitivity; (5) decrease myocardial infarct size; and (6) inhibit diabetic cardiomyopathy (DCM). 

Folic acid induces Lin28 expression and promotes insulin sensitivity

Figure 1. Mechanistic insights into how Folic acid functions as an anti-hyperglycemic/cardioprotective agent. Folic acid, by increasing the expression of reprogramming protein Lin-28, IGFIR, INSR, and IRS2, it may promote insulin sensitivity and protect from diabetic cardiomyopathy.

Thus, pharmacological formulations encompassing Folic acid or its analogues either alone or in combination with other drugs” may be used to treat DM and DCM.


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Amount: $ 300#

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does Folic acid promote insulin-sensitized state?

# Research cooperation


References: 

Web: http://genomediscovery.org or http://newbioideas.com/

CitationBoominathan L, Vitamin-based therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Folic acid promotes an insulin-sensitized state via up-regulation of  its target gene Lin-28, 10/March/2017, 10.53 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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