Amino acid therapy for Stroke: L-Leucine, a branched chain amino acid, augments regenerative neurogenesis after Ischemic Stroke and ameliorates stroke damage and neurological deficits via up regulation of its target gene NAMPT, 25/April/2017, 6.58 am

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Introduction: What they say

A recent study from the Department of Pharmacology, Second Military Medical University, Shanghai, China; Department of Science and Education, Shandong Provincial Hospital affiliated to Shandong University, Jinan, China; and Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (C.-Y.M.) shows that “Regenerative Neurogenesis After Ischemic Stroke Promoted by Nicotinamide Phosphoribosyltransferase-Nicotinamide Adenine Dinucleotide Cascade” This study was published, in the June 9 2015 issue of the journal Stroke,  by Prof  Miao CY, Zhao Y, and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Amino acid therapy for Stroke: L-Leucine, a branched chain amino acid, augments regenerative neurogenesis after Ischemic Stroke and ameliorates stroke damage and neurological deficits via up regulation of its target gene NAMPT  [easy_payment currency=”USD”]

price-200


From research findings to therapeutic opportunity: 

This study suggests that L-Leucine, by increasing the expression of of its target genes, it may: (1) increase the expression of NAMPT; (2) increase Sirtuins expression; (3) enhance neural stem cells; (4) promote neural functional recovery; (5) activate neuronal survival pathway; (6) promote post-ischemic regeneration after stroke; and (7) attenuate neurological deficits (Fig.1).

Figure 1. Mechanistic insights into how the branched chain amino acid L-Leucine promotes neural functional recovery after stroke. L-Leucine  promotes post-ischemic regeneration via up regulation of its target genes Sirtuins and NAMPT

Together, this study suggests that pharmacological formulations encompassing L-Leucine or its analogues either alone or in combination with other drugs” may be used to treat patients suffering from stroke and neurological deficits.

 

Details of the idea posted: 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $200#

Undisclosed mechanistic information: How L-Leucine increases the expression of NAMPT and promotes  regenerative neurogenesis after ischemic Stroke

For purchase and payment details, you may reach us at info@genomediscovery.org

# Research cooperation


References

Citation: Boominathan, L., Amino acid therapy for Stroke: L-Leucine, a branched chain amino acid, augments regenerative neurogenesis after Ischemic Stroke and ameliorates stroke damage and neurological deficits via up regulation of its target gene NAMPT, 25/April/2017, 6.58 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

Web: http://genomediscovery.org or http://newbioideas.com

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