Vitamin-based antiviral therapy against Neuroinvasive West Nile virus: Delta-Tocotrienol, a form of Vitamin-E, increases the expression of RIPK3, promotes chemokines production, inhibits neuroinflammation, and restricts neuroinvasive West Nile virus production and pathogenesis in neurons via up regulation of its target gene, 14/April/2017, 12.00 am

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Introduction: What they say

A study from the Department of Immunology, University of Washington, Seattle, WA 98109, USA; Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98109, USA shows that “RIPK3 Restricts Viral Pathogenesis via Cell Death-Independent Neuroinflammation.” This research paper was published in the 30 March 2017 issue of the journal “Cell” [One of the best research journals in General biology with an I.F of 28.710] by Prof. Andrew Oberst, Brian P. Daniels and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Vitamin-based antiviral therapy against Neuroinvasive West Nile virus: Delta-Tocotrienol, a form of Vitamin-E,  increases the expression of RIPK3, promotes chemokines production, inhibits neuroinflammation, and restricts neuroinvasive West Nile virus production and pathogenesis in neurons via up regulation of its target gene

Price 300[easy_payment currency=”USD”]


What is known?

Prof. Andrew Oberst’s research team has recently shown that mice deficient in Receptor-interacting protein kinase-3 (RIPK3): a) are highly susceptible to neuroinvasive West Nile virus (WNV); b) poorly induce chemokine expression in neurons; and c) poorly recruit T lymphocytes and inflammatory myeloid cells in central nervous system (CNS).


From Research findings to Therapeutic opportunity:

This study suggests, for the first time, a vitamin-based antiviral therapy against RNA viruses such as neuroinvasive West Nile virus (WNV).

Delta-Tocotrienol, by increasing the expression of its target gene, it may increase the expression of RIPK3 (Figure 1). Thereby, it may: (1) augment chemokine levels; (2) trigger neuroinflammation; (3) stall neuroinvasive West Nile virus replication; (4) promote clearance of neuroinvasive West Nile virus (WNV); and (5) strengthen antiviral immunity against RNA viruses.[easy_payment currency=”USD”]

nhibits WNV production via induction of RIPK3

Figure 1. Delta-tocotrienol (a form of Vitamin-E) functions as an antiviral agent. Delta-tocotrienol inhibits neuroinvasive West Nile virus (WNV) pathogenesis via up regulation of its target gene RIPK3

Thus, pharmacological formulations encompassing “Delta-Tocotrienol or its analogues either alone or in combination with any of the known antiviral compounds” may be used to treat infections caused by neuroinvasive West Nile virus (Figures 1-2 ).


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does Delta-Tocotrienol increase the expression of Receptor-interacting protein kinase-3 (RIPK3)?

Amount: $300#

For payment and purchase details, you may reach us at admin@genomediscovery.org

# Research cooperation


References:

Web: http://genomediscovery.org or http://newbioideas.com

Citation: Boominathan, L., Vitamin-based antiviral therapy against Neuroinvasive West Nile virus: Delta-Tocotrienol, a form of Vitamin-E,  increases the expression of RIPK3, promotes chemokines production, inhibits neuroinflammation, and restricts neuroinvasive West Nile virus production and pathogenesis in neurons via up regulation of its target gene, 14/April/2017, 12.00 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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