Natural product-derived antiviral therapy for HIV virus: Arctigenin, isolated from Greater Burdock (Arctium lappa) and Saussurea, increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 2/April/2017, 7.16 pm

Natural product-based therapy for TIIDM and obesity-associated metabolic deficits: Polydatin (PD), a longevity-promoting molecule isolated from Polygonum cuspidatum, among others, increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM via down regulation of its target gene, 2/April/2017, 8.50 am
April 2, 2017
Natural product-derived therapy for glucose homeostasis and TIIDM: Ankaflavin, secondary metabolites from Monascus-fermented products, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of their target gene, 3/April/2017, 7. 23 pm
April 3, 2017
Show all

What we say:

Dr L Boominathan PhD, Director-Price 100cum-chief Scientist of GBMD, reports that: Natural product-derived antiviral therapy for HIV virus: Arctigenin, isolated from Greater Burdock (Arctium lappa) and Saussurea, increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene

[easy_payment currency=”USD”]


From Significance of the study to Public health relevance:

Given that: (1) more than 37 million people worldwide are living with HIV/AIDS; (2) there is no effective vaccine available for HIV/AIDS; (3) HIV/AIDS tops the list of incurable diseases in humans; (4) the life-long painful drug treatment is required to treat HIV/AIDS and its associated opportunistic infections; (5) the global economic cost spent for HIV treatment is enormous, there is an urgent need to find: (i) a way to restore CD4 T-cells that were lost in HIV/AIDS; (ii) a cheaper alternative to the existing expensive antiviral drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, HIV-1/AIDS.


From Research findings to Therapeutic opportunity:

This study suggests, for the first time, a natural product-based antiviral therapy against RNA viruses such as HIV-1.

Arctigenin, by increasing the expression of its target gene, it may increase the expression of Heme oxygenase-2 (HO-2) (Figure 1). Thereby, it may: (1) bind and block the myristate moiety of HIV-1 Gag protein; (2) disrupt HIV-1 budding; (3) restrict HIV-1 infectivity, replication and production; (4) promote clearance of HIV-1 and MLV virions; and (5) strengthen antiviral immunity against RNA viruses.

Arctigenin inhibits HIV production

Figure 1 Mechanistic insights into how Arctigenin functions as an anti-HIV agent. Arctigenin inhibits HIV-1 budding and production via up-regulation of HO-2

Thus, pharmacological formulations encompassing “Arctigenin or its analogs either alone or in combination with other drugs” may be used to inhibit HIV-1 production.

[easy_payment currency=”USD”]


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does Arctigenin increase the expression of Heme oxygenase-2 (HO-2)?

Amount: $100#

For payment and purchase details, you may reach us at admin@genomediscovery.org

# Research cooperation


References:

Web: http://genomediscovery.org or http://newbioideas.com/

Citation: Boominathan, L., Natural product-derived antiviral therapy for HIV virus: Arctigenin, isolated from Greater Burdock (Arctium lappa) and Saussurea, increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 2/April/2017, 7.17 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite, drop us a line at admin@genomediscovery.org

Comments are closed.