Natural product-derived antiviral therapy for HIV virus: Genistein, an isoflavone isolated from Soy products, increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 10/April/2017, 12.01 am

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What we say:

Dr L Boominathan PhD, Director-Price 100cum-chief Scientist of GBMD, reports that: Natural product-derived antiviral therapy for HIV virus: Genistein, an isoflavone isolated from Soy products, increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene

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From Significance of the study to Public health relevance:

Given that: (1) more than 37 million people worldwide are living with HIV/AIDS; (2) there is no effective vaccine available for HIV/AIDS; (3) HIV/AIDS tops the list of incurable diseases in humans; (4) the life-long painful drug treatment is required to treat HIV/AIDS and its associated opportunistic infections; (5) the global economic cost spent for HIV treatment is enormous, there is an urgent need to find: (i) a way to restore CD4 T-cells that were lost in HIV/AIDS; (ii) a cheaper alternative to the existing expensive antiviral drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, HIV-1/AIDS.


From Research findings to Therapeutic opportunity:

This study suggests, for the first time, a natural product-based antiviral therapy against RNA viruses such as HIV-1.

Genistein, by increasing the expression of its target gene, it may increase the expression of Heme oxygenase-2 (HO-2) (Figure 1). Thereby, it may: (1) bind and block the myristate moiety of HIV-1 Gag protein; (2) disrupt HIV-1 budding; (3) restrict HIV-1 infectivity, replication and production; (4) promote clearance of HIV-1 and MLV virions; and (5) strengthen antiviral immunity against RNA viruses.

Genistein inhibits HIV1 production

Figure 1 Mechanistic insights into how Genistein functions as an anti-HIV agent. Arctigenin inhibits HIV-1 budding and production via up-regulation of HO-2

Thus, pharmacological formulations encompassing Genistein or its analogs either alone or in combination with other drugs” may be used to inhibit HIV-1 production.

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Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does Genistein increase the expression of Heme oxygenase-2 (HO-2)?

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References:

Web: http://genomediscovery.org or http://newbioideas.com/

Citation: Boominathan, L., Natural product-derived antiviral therapy for HIV virus:  Genistein, an isoflavone isolated from Soy products, increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 10/April/2017, 12.01 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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