Natural product-derived therapy therapy for Stroke: Asiatic acid, isolated from Centella Asiatica leaf, attenuates hippocampal neurons injury and ameliorates stroke damage and neurological deficits via up regulation of its target gene BDNF, 19/April/2017, 11.33 pm

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Introduction: What they say

A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; and School of Public Health, Xuzhou Medical College, PR China shows that “HO-1 attenuates hippocampal neurons injury via the activation of BDNF-TrkB-PI3K/Akt signaling pathway in stroke. This study was published, in the July 2  2014 issue of the journal Brain Research,  by Prof  Dong, Qi, and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy therapy for Stroke:  Asiatic acid, isolated from Centella Asiatica leaf, attenuates hippocampal neurons injury and ameliorates stroke damage and neurological deficits via up regulation of its target gene BDNF.

price-200


From research findings to therapeutic opportunity: 

This study suggests that Asiatic acid, by increasing the expression of of its target genes, it may: (1) increase the expression of BDNF; (2) augment neuronal–BDNF-TrkB-PI3K/Akt–survival pathway; (3) attenuate cerebral /Ischemia reperfusion injury; (4) inhibit neuronal apoptosis; (5) improve learning and memory; and (6) attenuate neurological deficits (Fig.1) 

Asiatic acid increases BDNF expressin and attenuates stroke

Figure 1. Mechanistic insights into how Asiatic acid  protects against stroke. Asiatic acid protects against stroke via up regulation of its target gene BDNF.

Together, this study suggests that pharmacological formulations encompassing Asiatic acid or its analogues either alone or in combination with other drugs” may be used to treat patients suffering from stroke and neurological deficits.


Details of the idea posted: 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $200#

Undisclosed mechanistic information: How Asiatic acid increases the expression of BDNF and attenuates stroke

For purchase and payment details, you may reach us at info@genomediscovery.org

# Research cooperation


References

Citation: Boominathan, L., Natural product-derived therapy therapy for Stroke:  Asiatic acid, isolated from Centella Asiatica leaf, attenuates hippocampal neurons injury and ameliorates stroke damage and neurological deficits via up regulation of its target gene BDNF, 19/April/2017, 11.33 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

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