Introduction: What they say
A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; and School of Public Health, Xuzhou Medical College, PR China shows that “HO-1 attenuates hippocampal neurons injury via the activation of BDNF-TrkB-PI3K/Akt signaling pathway in stroke.“ This study was published, in the July 2 2014 issue of the journal Brain Research, by Prof Dong, Qi, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy therapy for Stroke: Asiatic acid, isolated from Centella Asiatica leaf, attenuates hippocampal neurons injury and ameliorates stroke damage and neurological deficits via up regulation of its target gene BDNF.
From research findings to therapeutic opportunity:
This study suggests that Asiatic acid, by increasing the expression of of its target genes, it may: (1) increase the expression of BDNF; (2) augment neuronal–BDNF-TrkB-PI3K/Akt–survival pathway; (3) attenuate cerebral /Ischemia reperfusion injury; (4) inhibit neuronal apoptosis; (5) improve learning and memory; and (6) attenuate neurological deficits (Fig.1).
Together, this study suggests that pharmacological formulations encompassing “Asiatic acid or its analogues either alone or in combination with other drugs” may be used to treat patients suffering from stroke and neurological deficits.
Details of the idea posted:
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Undisclosed mechanistic information: How Asiatic acid increases the expression of BDNF and attenuates stroke
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Citation: Boominathan, L., Natural product-derived therapy therapy for Stroke: Asiatic acid, isolated from Centella Asiatica leaf, attenuates hippocampal neurons injury and ameliorates stroke damage and neurological deficits via up regulation of its target gene BDNF, 19/April/2017, 11.33 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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