Introduction: What they say
A recent study from From the Department of Pharmacology, Second Military Medical University, Shanghai, China; Department of Science and Education, Shandong Provincial Hospital affiliated to Shandong University, Jinan, China; and Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (C.-Y.M.) shows that “Regenerative Neurogenesis After Ischemic Stroke Promoted by Nicotinamide Phosphoribosyltransferase-Nicotinamide Adenine Dinucleotide Cascade” This study was published in the June 9 2015 issue of the journal Stroke by Prof Miao CY, Zhao Y, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy therapy for Stroke: Avicularin, a flavonol isolated from Polygonum aviculare, Rhododendron aureum and Taxillus kaempferi, augments regenerative neurogenesis after Ischemic Stroke and ameliorates stroke damage and neurological deficits via up regulation of its target gene NAMPT.
From research findings to therapeutic opportunity:
This study suggests that Avicularin, by increasing the expression of of its target genes, it may: (1) increase the expression of NAMPT; (2) increase Sirtuins expression; (3) enhance neural stem cells; (4) promote neural functional recovery; (5) activate neuronal survival pathway; (6) promote post-ischemic regeneration after stroke; and (7) attenuate neurological deficits (Fig.1).
Together, this study suggests that pharmacological formulations encompassing “Avicularin or its analogues either alone or in combination with other drugs” may be used to treat patients suffering from stroke and neurological deficits.
Details of the idea posted:
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Undisclosed mechanistic information: How Avicularin increases the expression of NAMPT and promotes regenerative neurogenesis after ischemic Stroke
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Citation: Boominathan, L., Natural product-derived therapy therapy for Stroke: Avicularin, a flavonol isolated from Polygonum aviculare, Rhododendron aureum and Taxillus kaempferi, augments regenerative neurogenesis after Ischemic Stroke and ameliorates stroke damage and neurological deficits via up regulation of its target gene NAMPT, 18/April/2017, 12.18 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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