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Introduction: What they say

A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; and School of Public Health, Xuzhou Medical College, PR China shows that “HO-1 attenuates hippocampal neurons injury via the activation of BDNF-TrkB-PI3K/Akt signaling pathway in stroke. This study was published, in the July 2  2014 issue of the journal Brain Research,  by Prof  Dong, Qi, and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy therapy for Stroke: Nectandrin B, a Nutmeg lignan, attenuates hippocampal neurons injury and ameliorates stroke damage and neurological deficits via up regulation of its target gene BDNF.

price-200


From research findings to therapeutic opportunity: 

This study suggests that Nectandrin B, by increasing the expression of of its target genes, it may: (1) increase the expression of BDNF; (2) augment neuronal–BDNF-TrkB-PI3K/Akt–survival pathway; (3) attenuate cerebral /Ischemia reperfusion injury; (4) inhibit neuronal apoptosis; (5) improve learning and memory; and (6) attenuate neurological deficits (Figs.1-2) 

Nectandrin B induces BDNF and alleviates stroke

Figure 1. Mechanistic insights into how Nectandrin B  protects against stroke. Nectandrin B protects against stroke via up regulation of its target gene BDNF.

nutmeg tree க்கான பட முடிவு

Figure 2. The Nutmeg component Nectandrin B  functions as an antistroke agent

Together, this study suggests that pharmacological formulations encompassing Nectandrin B or its analogues either alone or in combination with other drugs” may be used to treat patients suffering from stroke and neurological deficits.


Details of the idea posted: 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $200#

Undisclosed mechanistic information: How Nectandrin B increases the expression of BDNF and attenuates stroke

For purchase and payment details, you may reach us at info@genomediscovery.org

# Research cooperation


References

Citation: Boominathan, L., Natural product-derived therapy therapy for Stroke: Nectandrin B, a Nutmeg lignan, attenuates hippocampal neurons injury and ameliorates stroke damage and neurological deficits via up regulation of its target gene BDNF., 20/April/2017, 11.13 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

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