Introduction: What they say
A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; and School of Public Health, Xuzhou Medical College, PR China shows that “HO-1 attenuates hippocampal neurons injury via the activation of BDNF-TrkB-PI3K/Akt signaling pathway in stroke.“ This study was published, in the July 2 2014 issue of the journal Brain Research, by Prof Dong, Qi, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy therapy for Stroke: Nectandrin B, a Nutmeg lignan, attenuates hippocampal neurons injury and ameliorates stroke damage and neurological deficits via up regulation of its target gene BDNF.
From research findings to therapeutic opportunity:
This study suggests that Nectandrin B, by increasing the expression of of its target genes, it may: (1) increase the expression of BDNF; (2) augment neuronal–BDNF-TrkB-PI3K/Akt–survival pathway; (3) attenuate cerebral /Ischemia reperfusion injury; (4) inhibit neuronal apoptosis; (5) improve learning and memory; and (6) attenuate neurological deficits (Figs.1-2). [easy_payment currency=”USD”]
Together, this study suggests that pharmacological formulations encompassing “Nectandrin B or its analogues either alone or in combination with other drugs” may be used to treat patients suffering from stroke and neurological deficits.
Details of the idea posted:
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Undisclosed mechanistic information: How Nectandrin B increases the expression of BDNF and attenuates stroke
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# Research cooperation
Citation: Boominathan, L., Natural product-derived therapy therapy for Stroke: Nectandrin B, a Nutmeg lignan, attenuates hippocampal neurons injury and ameliorates stroke damage and neurological deficits via up regulation of its target gene BDNF., 20/April/2017, 11.13 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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