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April

April 27, 2017

Natural product therapy for TIIDM and Metabolic defects: Ursolic acid, found in Mirabilis Jalapa, Ocimum Sanctum, and apple peels among others, increases Sirtuin-4 expression, augments insulin secretion, reduces metabolic stress, improves glucose uptake, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 27/April/2017, 11.30 pm

Introduction: What they say A study from the “Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC […]
April 27, 2017

Molecular therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Serotonin reuptake inhibitor (SRI) antidepressant Fluoxetine (Trade names: Prozac and Sarafem) increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state via up-regulation of its target gene Lin28, 27/April/2017, 6.58 pm

Introduction: What they say:   A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows […]
April 27, 2017

Molecular therapy for Stroke: Lithium, a mood stabilizing agent used in the treatment of Bipolar disorder, augments regenerative neurogenesis after Ischemic Stroke and ameliorates stroke damage and neurological deficits via up regulation of its target gene NAMPT, 27/April/2017, 3.19 pm

Introduction: What they say A recent study from From the Department of Pharmacology, Second Military Medical University, Shanghai, China; Department of Science and Education, Shandong Provincial Hospital […]
April 27, 2017

Natural product therapy for Diabetic nephropathy (DN): Berberine, an isoquinoline alkaloid isolated from Berberis, Phellodendron amurense, Guduchi (Tinospora cordifolia/Amirthavalli), and Argemone mexicana among others, increases Pyruvate kinase M2 (PKM2) expression, decreases toxic glucose metabolites, mitochondrial dysfunction and apoptosis, augments glycolytic flux and PGC-1α levels, improves metabolic abnormalities, albuminuria, glomerular pathology, and renal dysfunction and alleviates diabetic nephropathy via down regulation of its target gene, 27/April/2017, 9.56 am

Introduction: What they say A study from the Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA shows that “Pyruvate kinase M2 activation may […]