Significance of the study:
It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan.
From research findings to therapeutic opportunity:
This study suggests, for the first time, that Laminar Shear stress, by increasing the expression of its target genes, it may decrease the expression of AT1R.
And, thereby, it may: (1) decrease blood pressure; (2) decrease blood sugar levels; (3) inhibit pulmonary fibrosis; (4) enhance bacterial immunity; (5) inhibit myocardial infarction; (6) increase telomerase expression, and decelerate ageing process; and (4) extend the lifespan of an individual.
Thus, physicians may consider encouraging their patients to undergo Laminar shear stress therapy, at regular intervals, to lead a healthy and long-life. Taken together, Laminar shear stress therapy may be used to extend the lifespan of an individual (Figure 1).
Details of the research findings:
Idea Proposed/Formulated by:
Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Undisclosed mechanistic information: How does Laminar Shear stress suppress the expression of angiotensin II type I receptor (AT1R)?
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# Research cooperation
Citation: Boominathan, L., Laminar Shear stress-based Lifespan extension therapy: Laminar Shear stress prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 9/May/2017, 8.53 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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