Bio-Magnetic-based PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Low-frequency magnetic field inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 31/May/2017, 11.04 pm

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Introduction:What they say:

A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA shows that “Deubiquitination and Stabilization of PD-L1 by CSN5.” This study was published in the 12 December 2016 issue of Cancer cell (one of the best journals in Cancer Science with an impact factor of 23.523) by Prof Mien-Chie Hung, Lim SO and others.


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Bio-Magnetic-based PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Low-frequency magnetic field inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene


What is known?

It has recently been shown that blocking cell surface receptor PD-1 with antibodies one could make tumors shrink. This work, relating to Cancer immunotherapy, has been chosen as Science’s breakthrough of the year recently.


From Research Findings to Therapeutic opportunity

Low frequency magnetic fields, by increasing the expression of its target genes, it may  diminish the expression of PD-L1 (fig. 1). Thereby, it may: (i) inhibit inflammatory TNFα signaling; (ii) decrease the number of tumor-infiltrating lymphocytes and macrophages; (iii) increase T-cell anti-tumor immunity; (iv) decrease tumor burden; and (v) increase survival of patients with breast cancer (fig. 1).  

Figure 1. Mechanistic insight into how Low frequency magnetic fields enhances the efficacy of cancer immunotherapy. Low frequency magnetic fields, by decreasing the expression of PD-L1 in cancer cells, it augments T-cell mediated anti-tumor immunity

Thus,  Low frequency magnetic field-based bio-magnetic therapy may be advised for cancer patients to (i) inhibit the progression of tumors; and (ii) enhance the efficacy of Cancer immunotherapy. Together,  oncologists may consider adopting Low frequency magnetic field-based bio-magnetic therapy in the treatment of Cancer.

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Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

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Amount: $50#

Undisclosed mechanistic information: How low-frequency magnetic field inhibits the expression of PD-L1 and augments anti-tumor immunity

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References

Citation: Boominathan, L., Bio-Magnetic-based PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Low-frequency magnetic field inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 31/May/2017, 11.04 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or http://newbioideas.com/

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