Molecular therapy for Stroke: Dimethyl Fumarate (DMF) and Monomethyl Fumarate (MMF) attenuate hippocampal neurons injury and ameliorate stroke damage and neurological deficits via up regulation of their target gene BDNF, 10/May/2017, 2.28 pm

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Introduction: What they say

A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; and School of Public Health, Xuzhou Medical College, PR China shows that “HO-1 attenuates hippocampal neurons injury via the activation of BDNF-TrkB-PI3K/Akt signaling pathway in stroke. This study was published, in the July 2  2014 issue of the journal Brain Research,  by Prof  Dong, Qi, and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy for Stroke: Dimethyl Fumarate (DMF) and  Monomethyl Fumarate (MMF) attenuate hippocampal neurons injury and ameliorate stroke damage and neurological deficits via up regulation of their target gene BDNF.

price-200


From research findings to therapeutic opportunity: 

This study suggests that  Dimethyl Fumerate (DMF) and Monomethyl Fumerate (MMF), by increasing the expression of of their target genes, they may: (1) increase the expression of BDNF; (2) augment neuronal–BDNF-TrkB-PI3K/Akt–survival pathway; (3) attenuate cerebral /Ischemia reperfusion injury; (4) inhibit neuronal apoptosis; (5) improve learning and memory; and (6) attenuate neurological deficits (Fig.1) [easy_payment currency=”USD”]

Figure 1. Mechanistic insights into how Dimethyl Fumerate (DMF) and Monomethyl Fumerate (MMF) protect against stroke. Both DMF and MMF protect against stroke via up regulation of their target gene BDNF (Brain-derived neurotrophic factor)

Together, this study suggests that pharmacological formulations encompassing “Dimethyl Fumerate (DMF) and Monomethyl Fumerate (MMF) or their analogues either alone or in combination with other drugs” may be used to treat patients suffering from stroke and neurological deficits.


Details of the idea posted: 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $200#

Undisclosed mechanistic information: How Dimethyl Fumerate (DMF) and Monomethyl Fumerate (MMF) increase the expression of BDNF and attenuate stroke

For purchase and payment details, you may reach us at info@genomediscovery.org

# Research cooperation


References

Citation: Boominathan, L., Molecular therapy for Stroke: Dimethyl Fumarate (DMF) and  Monomethyl Fumarate (MMF) attenuate hippocampal neurons injury and ameliorate stroke damage and neurological deficits via up regulation of their target gene BDNF, 10/May/2017, 2.28 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

Web: http://genomediscovery.org or http://newbioideas.com

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