Introduction:What they say:
A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK shows that “Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses.” This study was published, in the 16 February 2016 issue of Immunity (one of the best journals in Immunology with an impact factor of 20+), by Prof Rudd CE, Taylor A and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Music-based PD-1 pathway blockade for Human cancer therapy: Music therapy decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene
What is known?
It has recently been shown that blocking PD-1 with antibodies one could make tumors shrink. This work, relating to Cancer immunotherapy, has been chosen as Science’s breakthrough of the year.
From Research Findings to therapeutic opportunity:
Although it is known for years that music therapy has a positive impact on cancer patients health, but the mechanism of action remains unclear. This study suggests, for the first time, Music-based therapy for human cancers.
Music therapy, by inhibiting the activity of Glycogen synthase kinase 3-β (fig 1), it may: (a) increase transcription factor T-bet expression; (b) inhibit co-inhibitory receptor PD-1 expression; (c) increase CD8(+) cytotoxic T lymphocyte function; (d) augment anti-tumor activity; & (e) inhibit metastatic cancer progression (fig. 1).
Thus, by encouraging cancer patients to undergo music therapy, one may inhibit the progression of tumors. (Fig.1). Together, this study suggests, for the first time, that oncologists may consider recommending their patients to undergo music therapy.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.
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Undisclosed mechanistic information: How does Music therapy suppress the expression of PD-1 to promote anti-tumor immunity?
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Citation: Boominathan, L., Music-based PD-1 pathway blockade for Human cancer therapy: Music therapy decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 22/May/2017, 11.57 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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