What they say:
A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ) by Prof Dominic J. Withers, Dr. Selman C and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that: Natural product-derived Life-extension therapy: Puerarin, isolated from Pueraria lobata (Kudzu) and Pueraria montana, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span
Research findings to Therapeutic opportunity:
Puerarin, by increasing the expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (fig. 1).
Thus, pharmacological formulations encompassing “Puerarin or its analogs, either alone or in combination with any of the known longevity-promoting compound(s),“ may be used to extend the lifespan of an individual (figs. 1-2).
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Undisclosed mechanistic Information: How Puerarin decreases p70 S6 Kinase expression and promotes mammalian life span
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Citation: Boominathan, L., Natural product-derived Life-extension therapy: Puerarin, isolated from Pueraria lobata (Kudzu) and Pueraria montana, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 18/May/2017, 7.13 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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