Natural product-derived therapy for Metastatic cancers: Solasodine, found in Solanum melongena, increases the expression of metastasis suppressor BTG2 (B cell translocation gene 2 ) and the tumor suppressor INK4a , inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 7/May/2017, 11.24 pm

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From Significance of the study to Public health relevance:

Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them will die; (ii) cancer deaths globally are expected to be doubled by 2030; (iii) most of the cancer patients die due to metastasis; (iv) cancer treatment causes the highest economic loss compared to all the known causes of death worldwide, there is an urgent need to find: (i) bio-molecules that drive metastatic process; and the the way to prevent their expression; (ii) a way to activate immune system to combat cancer (Cancer immunotherapy); (ii) a cheaper alternative to the existing expensive anticancer drugs; (ii) a side-effect-free natural product-based drug; (iii) increase the therapeutic index of anticancer drugs; and (iv) a way to effectively treat and prevent metastatic progression and relapse of advanced/drug-resistant cancers.


Research findings to Therapeutic opportunity: 

A number of studies suggests that natural-product derived compound Solasodine inhibits tumor cell proliferation. However, the mechanism of action is far from clear.

This study suggests that Solasodine, by regulating the expression of its target genes, it may increase the expression of metastasis suppressor BTG2 (B cell translocation gene 2 ) and the tumor suppressor INK4a (fig. 1).

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Thereby, it may: (a) inhibit cell cycle progression; and (d) suppress migration, invasion and metastasis of cancer cells. Thus, pharmacological formulations encompassing Solasodine or its analogs either alone or in combination with other anticancer drugs” may be used to inhibit the progression of invasive tumors.


Details of the research findings

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Amount: $2

Undisclosed mechanistic information: How Solasodine increases the expression of metastasis suppressor BTG2 (B cell translocation gene 2 ) and the tumor suppressor INK4a

Fig1. Mechanistic insights into how Solasodine functions as an anti-metastasis agent. Solosodine increases the expression of metastasis suppressor BTG2 and the tumor suppressor INK4a/p16 via down regulation of its target genes.

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References

CitationBoominathan, L., Natural product-derived therapy for Metastatic cancers: Solasodine, found in Solanum melongena, increases the expression of metastasis suppressor BTG2 (B cell translocation gene 2 ) and the tumor suppressor INK4a , inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 7/May/2017, 11.24 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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