On the eve of Genome-2-Bio-Medicine Discovery center founder’s father’s (teacher) death anniversary day, we wish to inform you that the Bio-Medical ideas posted today (26/May/2017) will be available to the use of Scientists/Professors/Physicians/Researchers/Post-doctoral fellows/Teachers for free. So, there will be no terms and conditions for the ideas posted today (26/May/2017). Each idea posted will be served first come, first served basis. Write to us at email@example.com for more details.
Dr L Boominathan PhD
Founder President & CSO, GBMD.
Introduction: What they say
A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; and School of Public Health, Xuzhou Medical College, PR China shows that “HO-1 attenuates hippocampal neurons injury via the activation of BDNF-TrkB-PI3K/Akt signaling pathway in stroke.“ This study was published, in the July 2 2014 issue of the journal Brain Research, by Prof Dong, Qi, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Stroke: Hesperidin, isolated from Peppermint and blood orange, training attenuates hippocampal neurons injury and ameliorates stroke damage and neurological deficits via up regulation of its target gene BDNF
From research findings to therapeutic opportunity:
This study suggests that Hesperidin, by decreasing the expression of of its target genes, it may: (1) increase the expression of BDNF (Brain derived neurotrophic factor); (2) augment neuronal–BDNF-TrkB-PI3K/Akt–survival pathway; (3) attenuate cerebral /Ischemia reperfusion injury; (4) inhibit neuronal apoptosis; (5) improve learning and memory; and (6) attenuate neurological deficits (Figs.1-2). [easy_payment currency=”USD”]
Together, this study suggests that pharmacological formulations encompassing “Hesperidin or its analogues, either alone or in combination with other drugs,” may be used to treat patients suffering from stroke and neurological deficits.
Details of the idea posted:
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Undisclosed mechanistic information: How Hesperidin increases the expression of BDNF and attenuates stroke
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# Research cooperation
Citation: Boominathan, L., Natural product-derived therapy for Stroke: Hesperidin, isolated from Peppermint and blood orange, training attenuates hippocampal neurons injury and ameliorates stroke damage and neurological deficits via up regulation of its target gene BDNF., 26/May/2017, 11.07 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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