Natural product-derived therapy for Stroke: Withaferin (WA), isolated from Acnistus arborescens, and in Withania somnifera/Ashwagandha, augments regenerative neurogenesis after Ischemic Stroke and ameliorates stroke damage and neurological deficits via up regulation of its target gene NAMPT, 27/May/2017, 11.57 pm

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Introduction: What they say

A recent study from From the Department of Pharmacology, Second Military Medical University, Shanghai, China; Department of Science and Education, Shandong Provincial Hospital affiliated to Shandong University, Jinan, China; and Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (C.-Y.M.) shows that “Regenerative Neurogenesis After Ischemic Stroke Promoted by Nicotinamide Phosphoribosyltransferase-Nicotinamide Adenine Dinucleotide Cascade” This study was published, in the June 9 2015 issue of the journal Stroke,  by Prof  Miao CY, Zhao Y, and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Stroke: Withaferin (WA), isolated from Acnistus arborescens, and in Withania somnifera/Ashwagandha, augments regenerative neurogenesis after Ischemic Stroke and ameliorates stroke damage and neurological deficits via up regulation of its target gene NAMPT

price-200


From research findings to therapeutic opportunity: 

This study suggests that Withaferin (WA), by increasing the expression of of its target genes, it may: (1) increase the expression of NAMPT; (2) increase Sirtuins expression; (3) enhance neural stem cells; (4) promote neural functional recovery; (5) activate neuronal survival pathway; (6) promote post-ischemic regeneration after stroke; and (7) attenuate neurological deficits (Fig.1) [easy_payment currency=”USD”]

Figure 1. Mechanistic insights into how Withaferin (WA) promotes neural functional recovery after stroke. Withaferin (WA) promotes post-ischemic regeneration via up regulation of its target genes Sirtuins and NAMPT

Figure 2. Withaferin (WA) is found in Acnistus arborescens, and in Withania somnifera/Ashwagandha

Together, this study suggests that pharmacological formulations encompassing Withaferin (WA) or its analogues,  either alone or in combination with other drugs,” may be used to treat patients suffering from stroke and neurological deficits.


Details of the idea posted: 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $200#

Undisclosed mechanistic information: How Withaferin (WA) increases the expression of NAMPT and promotes  regenerative neurogenesis after ischemic Stroke

For purchase and payment details, you may reach us at info@genomediscovery.org

# Research cooperation


References

Citation: Boominathan, L., Natural product-derived therapy for Stroke: Withaferin (WA), isolated from Acnistus arborescens, and in Withania somnifera/Ashwagandha, augments regenerative neurogenesis after Ischemic Stroke and ameliorates stroke damage and neurological deficits via up regulation of its target gene NAMPT, 27/May/2017, 11.57 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

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