Natural product-derived therapy therapy for Stroke: 18β-Glycyrrhetinic Acid (18β-GA), isolated from Licorice, attenuates hippocampal neurons injury and ameliorates stroke damage and neurological deficits via up regulation of its target gene BDNF, 27/May/2017, 11.56 pm

Natural product-derived therapy for Metastatic cancers: Celastrol, isolated from Thunder God Vine, decreases the expression of metastasis promoters, such as Fibronectin-I, RhoE and Zeb1/2, increases the expression of metastasis suppressor E-Cadherin, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 26/May/2017, 11.10 pm
May 26, 2017
Natural product-derived therapy for Stroke: Withaferin (WA), isolated from Acnistus arborescens, and in Withania somnifera/Ashwagandha, augments regenerative neurogenesis after Ischemic Stroke and ameliorates stroke damage and neurological deficits via up regulation of its target gene NAMPT, 27/May/2017, 11.57 pm
May 27, 2017
Show all

Introduction: What they say

A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; and School of Public Health, Xuzhou Medical College, PR China shows that “HO-1 attenuates hippocampal neurons injury via the activation of BDNF-TrkB-PI3K/Akt signaling pathway in stroke. This study was published, in the July 2  2014 issue of the journal Brain Research,  by Prof  Dong, Qi, and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy therapy for Stroke: 18β-Glycyrrhetinic Acid (18β-GA), isolated from Licorice, attenuates hippocampal neurons injury and ameliorates stroke damage and neurological deficits via up regulation of its target gene BDNF.

price-200


From research findings to therapeutic opportunity:  This study suggests that 18β-Glycyrrhetinic Acid (18β-GA), by increasing the expression of of its target genes, it may: (1) increase the expression of BDNF; (2) augment neuronal–BDNF-TrkB-PI3K/Akt–survival pathway; (3) attenuate cerebral /Ischemia reperfusion injury; (4) inhibit neuronal apoptosis; (5) improve learning and memory; and (6) attenuate neurological deficits (Fig.1).  [easy_payment currency=”USD”]

Figure 1. Mechanistic insights into how 18β-Glycyrrhetinic Acid (18β-GA) protects against stroke. 18β-Glycyrrhetinic Acid (18β-GA) protects against stroke via up regulation of its target gene BDNF

Together, this study suggests that pharmacological formulations encompassing 18β-Glycyrrhetinic Acid (18β-GA) or its analogues, either alone or in combination with other drugs” may be used to treat patients suffering from stroke and neurological deficits.


Details of the idea posted: 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $200#

Undisclosed mechanistic information: How 18β-Glycyrrhetinic Acid (18β-GA) increases the expression of BDNF and attenuates stroke

For purchase and payment details, you may reach us at info@genomediscovery.org

# Research cooperation


References

Citation: Boominathan, L., Natural product-derived therapy therapy for Stroke: 18β-Glycyrrhetinic Acid (18β-GA), isolated from Licorice, attenuates hippocampal neurons injury and ameliorates stroke damage and neurological deficits via up regulation of its target gene BDNF, 27/May/2017, 11.56 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

Web: http://genomediscovery.org or http://newbioideas.com

Comments are closed.