Natural product-derived therapy therapy for Stroke: Oleuropein aglycone, isolated from Olive oil, attenuates hippocampal neurons injury, and ameliorates stroke damage and neurological deficits via up regulation of its target gene BDNF, 29/May/2017, 10.40 pm

Laminar shear stress-based therapy for Diabetic nephropathy (DN): Laminar flow-induced shear stress increases Pyruvate kinase M2 (PKM2) expression, decreases toxic glucose metabolites, mitochondrial dysfunction and apoptosis, augments glycolytic flux and PGC-1α levels, improves metabolic abnormalities, albuminuria, glomerular pathology, and renal dysfunction and alleviates diabetic nephropathy via down regulation of its target gene, 29/May/2017, 12.24 am
May 28, 2017
Natural product-derived therapy for Chronic Myeloid leukaemia (CML): Honokiol, isolated from Magnolia Grandiflora (MG), decreases the expression of Musashi2, inhibits cytosolic aminotransferase BCAT1 expression, decreases the intracellular production of BCAAs (Branched-chain amino acids), increases the expression of tumor suppressor genes, promotes differentiation of CML cells, and inhibits cancer progression in Myeloid leukemia via up-regulation of its target gene, 29/May/2017, 11.43 pm
May 29, 2017
Show all

Introduction: What they say

A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; and School of Public Health, Xuzhou Medical College, PR China shows that “HO-1 attenuates hippocampal neurons injury via the activation of BDNF-TrkB-PI3K/Akt signaling pathway in stroke. This study was published, in the July 2  2014 issue of the journal Brain Research,  by Prof  Dong, Qi, and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy therapy for Stroke:  Oleuropein aglycone, isolated from Olive oil, attenuates hippocampal neurons injury, and ameliorates stroke damage and neurological deficits via up regulation of its target gene BDNF.

price-200


From research findings to therapeutic opportunity: 

This study suggests that  Oleuropein aglycone, by increasing the expression of of its target genes, it may: (1) increase the expression of BDNF; (2) augment neuronal–BDNF-TrkB-PI3K/Akt–survival pathway; (3) attenuate cerebral /Ischemia reperfusion injury; (4) inhibit neuronal apoptosis; (5) improve learning and memory; and (6) attenuate neurological deficits (Figs.1-2) [easy_payment currency=”USD”]

Figure 1. Mechanistic insights into how Oleuropein aglycone protects against stroke. Oleuropein aglycone protects against stroke via up regulation of its target gene BDNF (Brain-derived growth factor).

Together, this study suggests that pharmacological formulations encompassing “Oleuropein aglycone or its analogues either alone or in combination with other drugs” may be used to treat patients suffering from stroke and neurological deficits.


Details of the idea posted: 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $200#

Undisclosed mechanistic information: How Oleuropein aglycone increases the expression of BDNF and attenuates stroke

For purchase and payment details, you may reach us at info@genomediscovery.org

# Research cooperation


References

Citation: Boominathan, L.,Natural product-derived therapy therapy for Stroke:  Oleuropein aglycone, isolated from Olive oil, attenuates hippocampal neurons injury, and ameliorates stroke damage and neurological deficits via up regulation of its target gene BDNF, 29/May/2017, 10.40 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

Web: http://genomediscovery.org or http://newbioideas.com

Comments are closed.