Anti-telomerase cancer therapy: Gallic acid (GA), isolated from Sumac, Gall Nuts, and Witch Hazel among others, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 12/May/2017, 11.54 pm
Introduction: What they say: The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.” This study provides mechanistic insights into how TPP1 regulates telomerase function. What we say: In connection with this finding, Dr Boominathan, Founder […]
Swimming as a therapeutic exercise for Stroke: Swimming training attenuates hippocampal neurons injury and ameliorates stroke damage and neurological deficits via up regulation of its target gene BDNF., 11/May/2017, 10.59 pm
Introduction: What they say A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; and School of Public Health, Xuzhou Medical College, PR China shows that “HO-1 attenuates hippocampal neurons injury via the activation of BDNF-TrkB-PI3K/Akt signaling pathway in stroke.“ This study was published, in the July 2 […]
Amino-acid-based therapy for glucose homeostasis and TIIDM: L-Leucine, an essential amino acid found abundantly in Parmesan cheese, soy and hemp seeds, inhibits Amysin expression, increases insulin secretion, and decreases the risk of hyperglycemia via down regulation of Sox4 and its target gene Amysin, 11/May/2017, 10.58 pm
Introduction: What they say Nobel laureate in Physiology/Medicine (1975) Prof. David Baltimore and his research team, from California Institute of Technology, California, USA, had reported in the September 14, 2014 issue of the Journal “Journal of Experimental Medicine (JEM)” that: “The microRNA-212/132 cluster regulates B cell development by targeting Sox4.” Subsequently, Prof. Rorsman’s research team, […]
Natural product-derived therapy for Metastatic human tumors: Myrtenal, isolated from Cardamom among others, decreases the expression of c-Src protein, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 11/May/2017, 10.57 pm
Introduction: What they say: A study from the State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China shows that “c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis.” This study was published in the 5 January 2017 issue of the […]
Laminar Shear stress-based therapy for Metabolic diseases: Laminar Shear stress increases the expression of Caveolin-1, stabilizes insulin receptor, promotes insulin sensitivity, incrases vasorelaxation, and decreases the risk of hyperglycemia and TIIDM via up regulation of its target gene., 11/May/2017, 10.56 pm
Introduction: What they say A study from the Institute for Molecular Systems Biology, ETH Zurich, Zurich, Switzerland shows that “MicroRNAs 103 and 107 regulate insulin sensitivity.” This study was published in the June 8, 2011 Nature [One of the best journals in Science with an I.F of >43] by Prof. Stoffel M, Trajkovski M and […]
Natural product therapy for pulmonary arterial hypertension:Gallic acid (GA), isolated from Sumac, Gall Nuts, and Witch Hazel among others, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 10/May/2017, 11.08 pm
What they say: A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November 2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others. What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of […]
