Music therapy for pulmonary arterial hypertension: Music therapy inhibits the development of pulmonary arterial hypertension via down regulation of Notch3 and its target gene Hes-5, 6/June/2017, 12.35 am

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What they say: 

A study from the University of California, La Jolla, California, USA shows that Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journalNature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Music therapy  for pulmonary arterial hypertension: Music therapy inhibits the development of pulmonary arterial hypertension via down regulation of  Notch3 and its target gene Hes-5


Significance of the study:  

Music therapyby increasing the expression of its target gene, it may decrease the expression of Notch3 and its target gene Hes-5 (Fig.1).  Thus, physicians/pulmonologists may consider recommending patients suffering from pulmonary arterial hypertension to undergo music therapy.

Figure 1. Mechanistic insights into how music therapy inhibits the development of pulmonary hypertension via up regulation of its target gene


Details of the research findings: 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Undisclosed mechanistic information: How music therapy decreases the expression of Notch3 and its target gene Hes-5

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References: 

Web: http://genomediscovery.org or http://newbioideas.com/

CitationBoominathan, L.,  Music therapy  for pulmonary arterial hypertension: Music therapy inhibits the development of pulmonary arterial hypertension via down regulation of  Notch3 and its target gene Hes-5, 6/June/2017, 12.35 am Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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