Natural product-derived Lifespan extension therapy: Isoliquiritigenin(ILQ), isolated from Licorice, prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 3/June/2017, 12.03 am

Narrow-band Ultraviolet B-based Anti-ageing and Life extension therapy: Narrow-band Ultraviolet B increases CHIP levels, increases monoubiquitylation of insulin receptor (INSR), decreases INSR protein levels and enhances lifespan via down regulation of its target gene, 2/June/2017, 11.51 pm
June 2, 2017
Molecular therapy for TIIDM and obesity-associated metabolic deficits: Kallistatin increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM via down regulation of its target gene, 3/June/2017, 12.15 am
June 2, 2017
Show all

Significance of the study:

It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan. 


From research findings to therapeutic opportunity: 

Figure1. Mechanistic insights into how Isoliquiritigenin(ILQ) functions as a longevity- promoter. Isoliquiritigenin(ILQ), by increasing the expression of its downstream target genes, down regulates A1TR expression and promotes longevity.

This study suggests, for the first time, that Isoliquiritigenin(ILQ), by increasing the expression of its target genes,  it may decrease the expression of AT1R.

And, thereby, it may: (1) decrease blood pressure; (2) decrease blood sugar levels; (3) inhibit pulmonary fibrosis; (4) enhance bacterial immunity; (5) inhibit myocardial infarction; (6) decelerate ageing process; and (4) extend the lifespan of an individual. Thus, pharmacological formulations encompassing Isoliquiritigenin(ILQ) or its analogues either alone or in combination with other anti-ageing/longevity promoting compounds may be used to extend the lifespan of an individual (Figure 1).

Price 300[easy_payment currency=”USD”]


Details of the research findings: 

Idea Proposed/Formulated by:

Dr L Boominathan Ph.D.  

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How  does Isoliquiritigenin(ILQ) suppress the expression of  angiotensin II type I receptor (AT1R)? 

Amount: $300#

For purchase and payment details, you may reach us at info@genomediscovery.org

#  Research cooperation


References

CitationBoominathan, L., Natural product-derived Lifespan extension therapy: Isoliquiritigenin(ILQ), isolated from Licoriceprolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 3/June/2017, 12.03 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com/

Courtesy: When you cite drop us a line at info@genomediscovery.org

Comments are closed.