Natural product-derived therapy for Metastatic cancers: Oleic acid, isolated from Olive oil, decreases the expression of metastasis promoters, such as Fibronectin-I, RhoE and Zeb1/2, increases the expression of metastasis suppressor E-Cadherin, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 5/June/2017, 12.05 am

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From Significance of the study to Public health relevance:

Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them will die; (ii) cancer deaths globally are expected to be doubled by 2030; (iii) most of the cancer patients die due to metastasis; (iv) cancer treatment causes the highest economic loss compared to all the known causes of death worldwide, there is an urgent need to find: (i) bio-molecules that drive metastatic process; and the the way to prevent their expression; (ii) a way to activate immune system to combat cancer (Cancer immunotherapy); (ii) a cheaper alternative to the existing expensive anticancer drugs; (ii) a side-effect-free natural product-based drug; (iii) increase the therapeutic index of anticancer drugs; and (iv) a way to effectively treat and prevent metastatic progression and relapse of advanced/drug-resistant cancers.


Research findings to Therapeutic opportunity: 

A number of studies suggests that Oleic acid inhibits tumor cell proliferation. However, the mechanism of action is far from clear.

This study suggests that Oleic acid, by regulating the expression of its target genes, it may decrease the expression of metastasis promoters such as Fibronectin-I, RhoE and Zeb1/2  and increase the expression of metastasis suppressor E-Cadherin (figs. 1-3).

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Thereby, it may: (a) inhibit cell cycle progression; and (d) suppress migration, invasion and metastasis of cancer cells. Thus, pharmacological formulations encompassing “Oleic acid or its analogs, either alone or in combination with other anticancer drugs,” may be used to inhibit the progression of invasive tumors.


Details of the research findings

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Amount: $10

Undisclosed mechanistic information: How Oleic acid decreases the expression of Fibronectin-I, RhoE and Zeb1/2 and increases the expression of  E-Cadherin

Fig1. Mechanistic insights into how Oleic acid functions as an anti-metastasis agent. Oleic acid increases the expression of metastasis suppressor E-cadherin and decrease the expression of Fibronectin-I, RhoE and Zeb1/2 via up regulation of its target genes.

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References

CitationBoominathan, L., Natural product-derived therapy for Metastatic cancers: Oleic acid, isolated from Olive oil, decreases the expression of metastasis promoters, such as Fibronectin-I, RhoE and Zeb1/2,  increases the expression of metastasis suppressor E-Cadherin, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 5/June/2017, 12.05 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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