Mechanical stretch-based regenerative therapy for reversing diabetes: Mechanical stretch increases the expression of Sox17, Sox2, Pdx-1, and Ngn3, decreases mTOR expression, promotes regeneration of insulin-producing ß cells, increases insulin secretion, promotes glucose homeostasis and reverses T1D and T2D via down regulation of its target gene, 11/July/2017, 10.10 pm

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Introduction: What they say

A study from the Longevity Institute, School of Gerontology, Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, California, USA; and Koch Institute at MIT, 500 Main Street, Cambridge, USA shows that “Fasting-Mimicking Diet Promotes Ngn3-Driven ß-Cell Regeneration to Reverse Diabetes.” This research paper was published in the 23 February 2017 issue of the journal “Cell” [One of the best research journals in Biology with an I.F of 28 plus] by Prof. and Director of Longevity institute Valter Longo, Cheng CW and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Mechanical stretch-based regenerative therapy for reversing diabetes: Mechanical stretch increases the expression of Sox17, Sox2, Pdx-1, and Ngn3, decreases mTOR expression, promotes regeneration of insulin-producing ß cells, increases insulin secretion, promotes glucose homeostasis and reverses T1D and T2D via down regulation of its target gene

Price 750


From Significance of the study to Public health relevance:

Given that: (1) more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) Diabetes is going to be one of the top 10 causes of death by 2030; (3) the life-long painful injection/drug treatment is required to treat DM; (3) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find: (i) a way to induce regeneration of adult ß-cells that were lost in DM; (ii) a cheaper alternative to the existing expensive weight-loss drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, diabetes.


What is known?

It has recently been shown that fasting mimicking diet (FMD):(1) increases the expression of Sox17, Pdx-1 (Pancreatic And Duodenal Homeobox 1), and Ngn3 (Neurogenin-3) sequentially; (2) promotes regeneration of insulin-producing ß cells; (3) decreases Protein Kinase A and mTOR activity; (4) increases reprogramming proteins Sox2 and Ngn3 expression; (5) increases insulin secretion; and (6) promotes glucose homeostasis, suggesting that FMD: (i) promotes reprogramming of pancreatic cells to restore insulin secretion in islets; and (ii) can reverse both T1D and T2D.


From Research findings to Therapeutic opportunity:

This study suggests, for the first time, a Mechanical stretchbased regenerative therapy for T1DM and TIIDM.

Mechanical stretch, by increasing the expression of its target genes, it may increase the expression of Sox17, Ngn3, Sox2, Pdx-1, NKX6.1, Pax6, INS etc. (Fig. 1). Thereby, it may: (1) decrease the expression of mTOR;  (2) increase generation of insulin-producing ß cells; (3) increase insulin secretion; and (4) promote glucose homeostasis, suggesting that L-Leucine–may replace the need for FMD or function as an effective alternative to FMD–may find its use in clinic in attenuating and/or reversing both T1D and T2D, as it turns on most of the reprogramming/insulin-producing genes turned by the FMD (Figs.1-3).

Given the mechanistic basis of mechanical stretch, physicians/diabetologists may consider adapting Mechanical stretch therapy in the treatment of treat and cure T1DM and T2DM. Taken together, Mechanical stretch therapy may be used to  treat and reverse treat and cure T1D and T2D.

Figure 1. Mechanistic insights into how Mechanical stretch, by turning on the expression of Ngn3, NKX6.1, Pax6, and INS among others genes, may promote reprogramming of pancreatic cells to restore insulin secretion in islets; and reverse both T1D and T2D.


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does Mechanical stretch increase the expression of Sox17, Sox2, Pdx-1, and Ngn3 to reprogram of pancreatic cells, to restore insulin secretion?

Amount: $ 750#

# Research cooperation

For purchase and payment details, you may reach us at info@genomediscovery.org


References:

Web: http://genomediscovery.org or http://newbioideas.com

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Citation: Boominathan, L., Mechanical stretch-based regenerative therapy for reversing diabetes: Mechanical stretch increases the expression of Sox17, Sox2, Pdx-1, and Ngn3, decreases mTOR expression, promotes regeneration of insulin-producing ß cells, increases insulin secretion, promotes glucose homeostasis and reverses T1D and T2D via down regulation of its target gene, 11/July/2017, 10.09 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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