Natural product-derived antiviral therapy for HIV virus: Artemisinin, isolated from Artemesia Annua L,  increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 27/July/2017, 11.15 pm

Mild Hypothermia-based therapy for heart regeneration and repair: Mild Hypothermia increases Agrin expression, activates Yap and ERK-mediated signaling,  replaces scar tissue with functional cardiomyocytes, and promotes cardiomyocyte regeneration and repair after myocardial infarction, via up regulation of its target gene, 27/July/2017, 11.08 pm
July 27, 2017
Combinatorial therapy for body weight control, energy homeostasis and TIIDM: A therapeutic mix encompassing Arctigenin and AICAR decreases CADM1 and its downstream target genes that promote glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM via up regulation of its target gene, 28/July/2017, 12.05 am
July 27, 2017
Show all

What we say:

Dr L Boominathan PhD, Director-Price 100cum-chief Scientist of GBMD, reports that: Natural product-derived antiviral therapy for HIV virus: Artemisinin, isolated from Artemesia Annua L,  increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene

[easy_payment currency=”USD”]


From Significance of the study to Public health relevance:

Given that: (1) more than 37 million people worldwide are living with HIV/AIDS; (2) there is no effective vaccine available for HIV/AIDS; (3) HIV/AIDS tops the list of incurable diseases in humans; (4) the life-long painful drug treatment is required to treat HIV/AIDS and its associated opportunistic infections; (5) the global economic cost spent for HIV treatment is enormous, there is an urgent need to find: (i) a way to restore CD4 T-cells that were lost in HIV/AIDS; (ii) a cheaper alternative to the existing expensive antiviral drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, HIV-1/AIDS.


From Research findings to Therapeutic opportunity:

This study suggests, for the first time, a natural product-based antiviral therapy against RNA viruses such as HIV-1.

Artemisinin, by increasing the expression of its target gene, it may increase the expression of Heme oxygenase-2 (HO-2) (Figure 1). Thereby, it may: (1) bind and block the myristate moiety of HIV-1 Gag protein; (2) disrupt HIV-1 budding; (3) restrict HIV-1 infectivity, replication and production; (4) promote clearance of HIV-1 and MLV virions; and (5) strengthen antiviral immunity against RNA viruses.

Figure 1 Mechanistic insights into how Artemisinin functions as an anti-HIV agent. Lipoic acid inhibits HIV-1 budding and production via up-regulation of its target gene HO-2

 

Thus, pharmacological formulations encompassing “Artemisinin or its analogs, either alone or in combination with other drugs,” may be used to inhibit HIV-1 production.

[easy_payment currency=”USD”]


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does Artemisinin increase the expression of Heme oxygenase-2 (HO-2)?

Amount: $100#

For payment and purchase details, you may reach us at admin@genomediscovery.org

# Research cooperation


References:

Web: http://genomediscovery.org or http://newbioideas.com/

Citation: Boominathan, L., Natural product-derived antiviral therapy for HIV virus: Artemisinin, isolated from Artemesia Annua L,  increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 27/July/2017, 11.15 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite, drop us a line at admin@genomediscovery.org

Comments are closed.