Natural product-derived Life-extension therapy: Artemisinin, isolated from Artemisia Annua, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 4/July/2017, 1.16 am

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What they say? 

A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ),  by Prof Dominic J. WithersDr. Selman C and others.


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMDreports, for the first time, that: Natural product-derived Life-extension therapy: Artemisinin, isolated from Artemisia Annua, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span


Research findings to Therapeutic opportunity: 

The antimalarial drug Artemisinin, discovered by Chinese chemist Tu Youyu, for which she won Noble prize in 2015, has also been shown to function as an anti-cancer agent. However, the detailed mechanistic insights is yet to emerge.

This study suggests, for the first time, that Artemisinin, by  increasing  the expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (fig. 1).   

Fig 1. Artemisinin may function as a longevity promoter by suppressing the expression of p70 S6 Kinase

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Thus, pharmacological formulations encompassing “Artemisinin either alone or in combination with any of the known longevity-promoting compound(s) may be used to extend the lifespan of an individual (fig. 1).


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

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Undisclosed mechanistic Information: How does Artemisinin decrease the expression of p70 S6 Kinase and promote mammalian life span?

# Research cooperation

Amount: $ 100#

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References:

CitationBoominathan, L.,  Natural product-derived Life-extension therapy: Artemisinin, isolated from Artemisia Annua, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 4/July/2017, 1.16 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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