Life-extension therapy: Nimbolide, isolated from Neem tree (Azadirachta indica), inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 1/August/2017, 11.55 pm

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What they say:

A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ) by Prof Dominic J. Withers, Dr. Selman C and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that:  Life-extension therapy: Nimbolide, isolated from Neem tree (Azadirachta indica), inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span


Research findings to Therapeutic opportunity: 

Figure 1. Mechanistic insight into how Nimbolide may extend lifespan. Nimbolide may promote longevity by suppressing the expression of p70 S6 kInase

Nimbolide, by  increasing  the expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (fig. 1).   

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Thus, pharmacological formulations encompassing Nimbolide or its analogs, either alone or in combination with any of the known longevity-promoting compound(s)” may be used to extend the lifespan of an individual (fig. 1).


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

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Undisclosed mechanistic Information: How  Nimbolide decreases the expression of p70 S6 Kinase and promotes mammalian life span

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References:

CitationBoominathan, L.,    Life-extension therapy: Nimbolide, isolated from Neem tree (Azadirachta indica), inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 1/August/2017, 11.55 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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