Natural product-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing Baicalein, DIM, and Cholecalciferol activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via up regulation of its target gene ATG5 (Autophagy related 5), 1/September/2017, 1.46 am

Molecular therapy for glucose homeostasis and TIIDM: Rivaroxaban (Brand name: Xarelto) increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 1/September/2017, 1.37 am
August 31, 2017
 Natural product-based PD-1 pathway blockade for Human cancer therapy: Lovastatin, a cholesterol lowering drug, decreases the expression of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 1/September, 2017, 10.54 pm
September 1, 2017
Show all

Introduction: What they say

A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was published, in the online journal “Nature communications”,  by Prof. Jung YK, Pyo Jo and others.

Earlier, Prof. Yoshinori Ohsumi, from Institute of Innovative Research, Tokyo Institute of Technology, who won the Nobel prize in Physiology or Medicine, in 2016, discovered the mechanisms of Autophagy, including the role of of ATG5 in the regulation of autophagy.


What we say: 

On the foundation of these interesting findings, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:   Natural product-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing Baicalein, DIM, and Cholecalciferol activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via up regulation of its target gene ATG5 (Autophagy related 5)


From research findings to therapeutic opportunity: 

This study suggests, for the first time, that a therapeutic mix encompassing Baicalein, DIM, and Cholecalciferol, by increasing the expression of its target genes, it may increase the expression of ATG5. Thereby, it may: (1) enhance autophagy, (2) promote leanness; (3) increase insulin sensitivity; (4) improve motor function; and (5) alleviate ageing features (Fig.1).

Figure1. A therapeutic mix encompassing Baicalein, DIM, and Vitamin-D functions as a longevity promoting agent. The therapeutic mix, as mentioned above, increases ATG5 expression and promotes leanness, insulin sensitivity, motor function and longevity.

[easy_payment currency=”USD”]

Thus, pharmacological formulations encompassing “Baicalein, DIM, and Cholecalciferol or their analogues either alone or in combination with other longevity-promoting drugs or compounds” may be used to increase the lifespan of an individual (Fig.1).


Details of the research findings: 

Idea Proposed/Formulated by: Dr L Boominathan PhD

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $500#

For payment and purchase information, you may reach us at info@genomediscovery.org

# Research cooperation


References: 

Web: http://genomediscovery.org or newbioideas.com/

To cite: Boominathan, L., Natural product-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing Baicalein, DIM, and Cholecalciferol activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via up regulation of its target gene ATG5 (Autophagy related 5), 1/September/2017, 1.46 am

Courtesy: When you cite us, just drop us a line at info@genomediscovery.org

 

Comments are closed.