Natural product therapy for pulmonary arterial hypertension: Curcumin, isolated from Turmeric, inhibits the development of pulmonary arterial hypertension via down regulation of  Notch3 and its target gene Hes-5, 28/August/2017, 12.14 am

Natural product-derived Combinatorial therapy targeting CMTM6/4-PD-L1 pathway enhances the efficacy of Cancer immunotherapy: A therapeutic mix encompassing Berberine , Nimbolide and N-Acetylcysteine (BNN) inhibits the expression of transmembrane protein CMTM6/CMTM4, increases interferon-IFNγ signalling, augments antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 27/August/2017, 3.48 pm
August 27, 2017
Natural product-derived therapy for Acute Myeloid Leukemia: A therapeutic mix encompassing Ivermectin and Curcumin  decreases the expression of BCLAF1,  promotes differentiation of acute myeloid leukemic cells, restores treatment responsiveness, increases therapeutic index of anticancer drugs, and promotes regression of AML via up-regulation of its target gene, 28/August/2017, 12.23 am
August 27, 2017
Show all

What they say: 

A study from the University of California, La Jolla, California, USA shows that Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product therapy for pulmonary arterial hypertension: Curcumin, isolated from Turmeric, inhibits the development of pulmonary arterial hypertension via down regulation of  Notch3 and its target gene Hes-5


Significance of the study:  

Curcuminby increasing the expression of its target gene, it may decrease the expression of Notch3 and its target gene Hes-5 (Fig.1).  Thus, pharmacological formulations encompassing “Curcumin or its analogs, either alone or in combination with other drugs” may be used to treat pulmonary arterial hypertension.

Figure 1. Mechanistic insights into how Curcumin (CUR) inhibits the development of pulmonary hypertension via up regulation of its target gene decreases the expression of Notch3


Details of the research findings:

Amount: $100#

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How Silymarin inhibits Notch-3 expression

For purchase and payment details, you may reach us at info@genomediscovery.org

# Research cooperation


References: 

Web: http://genomediscovery.org or http://newbioideas.com/

CitationBoominathan, L.,  Natural product therapy for pulmonary arterial hypertension: Curcumin, isolated from Turmeric, inhibits the development of pulmonary arterial hypertension via down regulation of  Notch3 and its target gene Hes-5, 28/August/2017, 12.14 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite us, drop us a line at info@genomediscovery.org

Comments are closed.