August

August 27, 2017

Natural product-derived Combinatorial therapy targeting CMTM6/4-PD-L1 pathway enhances the efficacy of Cancer immunotherapy: A therapeutic mix encompassing Berberine , Nimbolide and N-Acetylcysteine (BNN) inhibits the expression of transmembrane protein CMTM6/CMTM4, increases interferon-IFNγ signalling, augments antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 27/August/2017, 3.48 pm

Introduction:What they say: A recent study from Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Plesmanlaan, CX Amsterdam, The Netherlands has identified CMTM6 and […]
August 27, 2017

Antiviral therapy for chikungunya (CHIKV) and Zika (ZIKV) viruses: Ivermectin (Brand name: Heartguard/Mectizen/Stromectol), the antihelminthic drug, increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via up regulation of its target gene, 27/August/2017, 9. 14 am

Introduction: What they say A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex […]
August 27, 2017

Molecular therapy for Metastatic cancers: Myrtenal, isolated  from Taxus, increases the expression of metastasis/tumor suppressors  BTG2 and INK4a, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 27/August/2017, 8.25 am

From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more […]
August 27, 2017

Molecular-therapy for Regenerating the lost pancreatic β-cells in Diabetic patients:  β-Cryptoxanthin (BCX), isolated from Paprika, Buah Merah, Papaya, and Satsuma Mandarin, among others, increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state via up-regulation of  its target gene Lin28, 27/August/2017, 8.10 am

Introduction: What they say:   A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis […]