October

October 31, 2017

Published by admin_auro at October 31, 2017

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Molecular therapy for muscle atrophy and wasting:Rivaroxaban (Trade name: Xarelto), an anticoagulant (blood thinner), increases the expression of FGF19 and its receptor ß-Klotho, phosphorylates ERK1/2 and S6K1, decreases the expression of tumor suppressors genes, promotes regeneration of muscle cells and hypertrophy of skeletal muscle, and reverses muscular atrophy and wasting via up regulation of its target gene, 1/November/2017, 4.33 am

Introduction: What they say A study from Department of Biology, University of Bergen, Bergen, Norway; and Univ-Lyon, CarMeN Laboratory, INSERM 1060, INRA 1397, Université Claude Bernard Lyon, INSA Lyon, Oullins, France […]

October 31, 2017

Published by admin_auro at October 31, 2017

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Molecular therapy for TIIDM and Metabolic defects: Ezetimibe (Trade name: Zetia or Ezetrol), a cholesterol lowering medication, increases Sirtuin-4 expression, augments insulin secretion, reduces metabolic stress, improves glucose uptake, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 31/October/2017, 11.11 am

Introduction: What they say A study from the “Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC […]

October 31, 2017

Published by admin_auro at October 31, 2017

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Antiviral therapy for HIV virus: Ribavirin/Tribavirin, an antiviral medication used in the treatment of RSV infection, hepatitis C, and viral hemorrhagic fever, increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 31/October/2017, 10.43am

Introduction: What they say A study from the Department of Biochemistry and Molecular Biophysics and Department of Microbiology and Immunology, Howard Hughes Medical Institute, Columbia University, […]

October 31, 2017

Published by admin_auro at October 31, 2017

Categories

Ageing
Ideas

Natural product-based combinatorial therapy for ageing-associated diseases and Lifespan extension: A therapeutic mix encompassing iallyl disulfide, Isoorientin and Resveratrol (DIR) increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer and aging via down regulation of its target gene, 31/September/2017, 10.35 am

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]