Antiviral therapy for HIV virus: Nimesulide, a drug used to relieve pain,  increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 15/October/2017, 1.14 am

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What we say:

Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Antiviral therapy for HIV virus: Nimesulide, a drug used to relieve pain,  increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene

 

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From Significance of the study to Public health relevance:

Given that: (1) more than 37 million people worldwide are living with HIV/AIDS; (2) there is no effective vaccine available for HIV/AIDS; (3) HIV/AIDS tops the list of incurable diseases in humans; (4) the life-long painful drug treatment is required to treat HIV/AIDS and its associated opportunistic infections; (5) the global economic cost spent for HIV treatment is enormous, there is an urgent need to find: (i) a way to restore CD4 T-cells that were lost in HIV/AIDS; (ii) a cheaper alternative to the existing expensive antiviral drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, HIV-1/AIDS.


From Research findings to Therapeutic opportunity:

This study suggests, for the first time, a small-molecule based antiviral therapy against RNA viruses such as HIV-1.

Nimesulide , by increasing the expression of its target gene, it may increase the expression of Heme oxygenase-2 (HO-2) (Figure 1). Thereby, it may: (1) bind and block the myristate moiety of HIV-1 Gag protein; (2) disrupt HIV-1 budding; (3) restrict HIV-1 infectivity, replication and production; (4) promote clearance of HIV-1 and MLV virions; and (5) strengthen antiviral immunity against RNA viruses. Thus, pharmacological formulations encompassing “Nimesulide or its analogues, either alone or in combination with other anti-HIV drugs” may be used to treat HIV infection. Given that it is relatively cheaper compared to other anti-HIV drugs in the market, it may an ideal drug for further experimentation and validation.

Figure 1 Mechanistic insights into how Nimesulide functions as an anti-HIV agent. Nimesulide inhibits HIV-1 budding and production via up-regulation of its target gene HO-2

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Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does Nimesulide increase the expression of Heme oxygenase-2 (HO-2)?

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References:

Web: http://genomediscovery.org or http://newbioideas.com/

Citation: Boominathan, L.,  Antiviral therapy for HIV virus: Nimesulide, a drug used to relieve pain,  increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 15/October/2017, 1.20 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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