What they say:
A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published, in the 15 November 2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054], by Prof. Thistlethwaite PA, Li X and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product therapy for pulmonary arterial hypertension: Tanshinone IIA, one of the main components of Salvia miltiorrhiza, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3
Significance of the study:
Tanshinone IIA, by increasing the expression of its target gene, it may decrease the expression of Notch3 and its target gene Hes-5 (Fig.1).
Thus, pharmacological formulations encompassing “Tanshinone IIA or its analogues, either alone or in combination with other drugs, may be used to treat pulmonary arterial hypertension.
Details of the research findings:
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Undisclosed mechanistic information: How Tanshinone IIA decreases the expression of Notch3
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# Research cooperation
Citation: Boominathan, L., Natural product therapy for pulmonary arterial hypertension: Tanshinone IIA, one of the main components of Salvia miltiorrhiza, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 29/October/2017, 7.40 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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