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November

November 30, 2017

Activation of the PD-1 pathway for Pain therapy: Glycine, a non-essential amino acid and neurotransmitter, increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 1/December/2017, 12.36 am

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
November 30, 2017

Molecular therapy for muscle atrophy and wasting: Cilostazol, a phosphodiesterase inhibitor used in the treatment of Peripheral vascular disease, increases the expression of FGF19 and its receptor ß-Klotho, phosphorylates ERK1/2 and S6K1, decreases the expression of tumor suppressors  genes, promotes regeneration of muscle cells and hypertrophy of skeletal muscle, and reverses muscular atrophy and wasting via up regulation of its target gene, 1/December/2017, 12.03 am

Introduction: What they say A study from Department of Biology, University of Bergen, Bergen, Norway; and Univ-Lyon, CarMeN Laboratory, INSERM 1060, INRA 1397, Université Claude Bernard […]
November 30, 2017

Natural product-based therapy for body weight control, energy homeostasis and TIIDM: Formononetin, isolated from Trifolium pratense,  inhibits DNA methyltransferase 3a (Dnmt3a) expression, increases FGF21 expression, augments insulin sensitivity, increases glucose tolerance, and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 30/November/2017, 11.49 pm

Introduction: What they say A study from Nutritional Sciences and Toxicology Department, University of California, Berkeley, Berkeley, United States shows that “Dnmt3a is an epigenetic mediator […]
November 30, 2017

Regenerative therapy for reversing and/or attenuating diabetes: Cilostazol, a phosphodiesterase inhibitor used in the treatment of Peripheral vascular disease, decreases mTOR expression, promotes regeneration of insulin-producing ß cells, increases insulin secretion, promotes glucose homeostasis and reverses T1D and T2D via down regulation of its target gene, 30/November/2017, 10.43 pm

Introduction: What they say A study from the Longevity Institute, School of Gerontology, Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, […]