Combinatorial Antiviral Therapy (CAT): A pharmaceutical mixture encompassing Andrographolide and Nordihydroguaiaretic acid (NDGA) inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, SARS. Influenza H1NI1,  respiratory syncytical ,  Sindbis, and SFV viruses by increasing the Levels of the Antiviral Proteins IFITM3, & Interferon-stimulated gene 15, 7/November/2017,  12.27 am

Molecular therapy for heart regeneration and repair: A therapeutic mix encompassing Atorvastatin and Amlodipine increases Agrin expression, activates Yap and ERK-mediated signaling,  replaces scar tissue with functional cardiomyocytes, and promotes cardiomyocyte regeneration and repair after myocardial infarction, via up regulation of its target gene, 7/November/2017, 12.03 am
November 6, 2017
Lifespan extension therapy: 5,4′-dihydroxy-7,8-dimethoxyflavanone (DHDMF), found abundantly in Dodonaea viscosa,  may increase life span via up-regulation of its target gene BubR1, 7/November/2017, 9.17 am
November 7, 2017
Show all

Introduction: What they say: 

A study from the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA shows that “The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.” This study was published, in the 24 December 2009 issue of the journal “Cell” (the number 1 research journal in General Biology with an impact factor of 33),  by the 2015 Laskar award winner Prof. Stephen Elledge, Brass and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Combinatorial Antiviral Therapy (CAT): A pharmaceutical mixture encompassing Andrographolide and Nordihydroguaiaretic acid (NDGA) inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, SARS. Influenza H1NI1,  respiratory syncytical ,  Sindbis, and SFV viruses by increasing the Levels of the Antiviral Proteins IFITM3, & Interferon-stimulated gene 15


What is known?

Prof. Stephen Elledge research team has showed that interferon-inducible transmembrane proteins IFITM1, 2, and 3 inhibit  influenza A H1N1 virus, West Nile virus, and dengue virus replication, suggesting that increasing the expression of IFITM3 may confer resistance against these viruses. Other studies suggest that IFITM3 may also protect against Ebola virus, hepatitis C virus, yellow fever virus and SARS coronavirus etc.


From research findings to therapeutic opportunity: 

This study suggests, for the first time, that a pharmaceutical mixture encompassing Andrographolide and Nordihydroguaiaretic acid (NDGA), by decreasing the expression of its target genes, it may increase the expression of interferon-inducible transmembrane protein IFITM3, Interferon-stimulated gene-15, Mx2 and antimicrobial peptides. Thereby, it may: (1) inhibit the replication of  Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial,  Sindbis, and SFV viruses; (2) confer resistance against  infection caused by Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytical,  Sindbis, and SFV viruses; and (3) promote innate immunity (Figure 1) Thus, pharmacological formulations encompassing “Andrographolide and Nordihydroguaiaretic acid (NDGA) or their analogues” may be used to prevent/treat infections caused by Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, SARS, Influenza H1NI1,  respiratory syncytical,  Sindbis, and SFV viruses (Figure 2).

Figure 1. Mechanistic insight into how a pharmaceutical mixture encompassing Andrographolide and Nordihydroguaiaretic acid (NDGA) inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial , Sindbis, and SFV viruses production through induction of its target genes, such as Antiviral Proteins IFITM3, Interferon-stimulated gene 15, & Mx2

Figure 2. The chemical structures of Artemisinin and Suramin. A pharmaceutical mixture encompassing Andrographolide and Nordihydroguaiaretic acid (NDGA) may function as a broad-spectrum antiviral agent against a number of infections caused by viruses.

 


Details of the research findings: 

Idea formulated by Dr L Boominathan PhD

Undisclosed information: How a pharmaceutical mixture encompassing Andrographolide and Nordihydroguaiaretic acid (NDGA) increases the expression of Antiviral Protein IFITM3, , Interferon-stimulated gene 15, & Mx2

Amount: $1, 500

# Research cooperation

For more details on payment, you may reach us at admin@genomediscovery.org


References: 

CitationBoominathan L, Combinatorial Antiviral Therapy (CAT): A pharmaceutical mixture encompassing Andrographolide and Nordihydroguaiaretic acid (NDGA) inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, SARS. Influenza H1NI1,  respiratory syncytical ,  Sindbis, and SFV viruses by increasing the Levels of the Antiviral Proteins IFITM3, & Interferon-stimulated gene 15, 7/November/2017,  12.27 am


Courtesy:
 When you cite drop us a line at info@genomediscovery.org,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org

Comments are closed.