What they say: Introduction:
A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published, in the 1 July 2014 issue of the journal “EMBO”, by Prof Sinclair, North BJ, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Lifespan extension therapy: 5,4′-dihydroxy-7,8-dimethoxyflavanone (DHDMF), found abundantly in Dodonaea viscosa, may increase life span via up-regulation of its target gene BubR1
What is known?
5,4′-dihydroxy-7,8-dimethoxyflavanone (DHDMF) has been shown to possess anti-hyperglycemic activity. However, the exact mechanism of action is far from clear.
From Research Findings to Therapeutic Opportunity:
This study suggests, for the first time, that Tetrahydrocannabinolic acid [THCA], by increasing the expression of its target gene, it may: (a) increase the expression of BuBR1; (b) decrease the expression of p70 S6 Kinase; and (c) regulate the expression of a number of longevity-promoting molecules (Fig. 1).
Thereby, it may: (1) increase insulin sensitivity; (2) increase thermogenesis, lipolysis and oxidative metabolism; (3) inhibit obesity; (4) attenuate cognitive impairment; (5) delay diseases of aging; (6) slow down cardiac aging; (7) promote resistance to bone, immune and motor dysfunction; (8) promote tissue rejuvenation; and (9) prolong median life span. Thus, pharmacological formulations encompassing “Tetrahydrocannabinolic acid [THCA] or its analogues, either alone or in combination with other drugs” may be used to extend the lifespan of an individual (fig. 1).
Details on the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Undisclosed mechanistic information: How a pharmaceutical mix encompassing 5,4′-dihydroxy-7,8-dimethoxyflavanone (DHDMF) increases the expression of BubR1 and extends mammalian life-span
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# Research cooperation
Citation: Boominathan, L., Lifespan extension therapy: 5,4′-dihydroxy-7,8-dimethoxyflavanone (DHDMF), found abundantly in Dodonaea viscosa, may increase life span via up-regulation of its target gene BubR1, 7/November/2017, 9.15 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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