Natural product therapy for pulmonary arterial hypertension:Mangiferin, isolated from Mangifera Indica, inhibits the development of pulmonary arterial hypertension via down regulation of  Notch3 and its target gene Hes5, 11/November/2017, 11.59 pm

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What they say: 

A study from the University of California, La Jolla, California, USA shows that Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product therapy for pulmonary arterial hypertension:Mangiferin, isolated from Mangifera Indica, inhibits the development of pulmonary arterial hypertension via down regulation of  Notch3 and its target gene Hes5


Significance of the study:  

Mangiferin, by increasing the expression of its target gene, it may decrease the expression of Notch3 and its target gene Hes-5 (Fig.1).  Thus, pharmacological formulations encompassing “Mangiferin or its analog, either alone or in combination with other drugs” may be used to treat pulmonary arterial hypertension.

Figure 1. Mechanistic insights into how Mangiferin inhibits the development of pulmonary hypertension.


Details of the research findings:

Idea formulated by : Dr. L Boominathan PhD

Amount: $100#

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Undisclosed mechanistic information: How Mangiferin inhibits Notch-3 expression

For purchase and payment details, you may reach us at info@genomediscovery.org

# Research cooperation


References: 

Web: http://genomediscovery.org or http://newbioideas.com/

CitationBoominathan, L.,  Natural product therapy for pulmonary arterial hypertension:Mangiferin, isolated from Mangifera Indica, inhibits the development of pulmonary arterial hypertension via down regulation of  Notch3 and its target gene Hes5, 11/November/2017, 11.59 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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