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December 10, 2017

Molecular therapy for heart regeneration and repair: A therapeutic mix encompassing Trimetazidine (TMZ) and Astaxanthin (ATX) [TMZATX]  increases Agrin expression, activates Yap and ERK-mediated signaling,  replaces scar tissue with functional cardiomyocytes, and promotes cardiomyocyte regeneration and repair after myocardial infarction, via up regulation of its target gene, 10/December/2017, 10.45 pm

Introduction: What they say: A recent study from Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel; Department of Biomedical Engineering, Duke University, […]
December 10, 2017

Natural product-based therapy for body weight control, energy homeostasis and TIIDM: Carvedilol[Trade name: Coreg], Nonselective beta/alpha1 blocker used in the treatment of myocardial dysfunction and hypertension, inhibits DNA methyltransferase 3a (Dnmt3a) expression, increases FGF21 expression, augments insulin sensitivity, increases glucose tolerance, and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 10/December/2017, 9.59 am

Introduction: What they say A study from Nutritional Sciences and Toxicology Department, University of California, Berkeley, Berkeley, United States shows that “Dnmt3a is an epigenetic mediator […]
December 10, 2017

Activation of the PD-1 pathway for Pain therapy: Punicalagin, isolated from Pomegranate,  increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 10/December/2017, 7.13 am

Introduction:What they say: A recent study, from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
December 10, 2017

Amino acid-based therapy for Non-alcoholic fatty liver disease (NAFLD): D-Serine promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD) via down regulation of its target gene, 10/December/2017, 6.07 am

Significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while only 6-25% of Asian populations suffer from it; […]