Introduction: What they say
A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; and School of Public Health, Xuzhou Medical College, PR China shows that “HO-1 attenuates hippocampal neurons injury via the activation of BDNF-TrkB-PI3K/Akt signaling pathway in stroke.“ This study was published, in the July 2 2014 issue of the journal Brain Research, by Prof Dong, Qi, and others.
Another study from the Department of Pharmacology, Second Military Medical University, Shanghai, China; Department of Science and Education, Shandong Provincial Hospital affiliated to Shandong University, Jinan, China; and Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (C.-Y.M.) shows that “Regenerative Neurogenesis After Ischemic Stroke Promoted by Nicotinamide Phosphoribosyltransferase-Nicotinamide Adenine Dinucleotide Cascade” This study was published, in the June 9 2015 issue of the journal Stroke, by Prof Miao CY, Zhao Y, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy for Stroke: Cilostazol, a phosphodiesterase inhibitor used in the treatment of Peripheral vascular disease, attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits via up regulation of its target genes BDNF and NAMPT
From research findings to therapeutic opportunity:
This study suggests that Cilostazol, by increasing the expression of of its target genes, it may: (1) increase the expression of BDNF and NAMPT (Nicotinamide Phosphoribosyltransferase-Nicotinamide Adenine Dinucleotide); (2) augment neuronal–BDNF-TrkB-PI3K/Akt–survival pathway; (3) increase Sirtuins expression; (4) enhance neural stem cells; (5) promote neural functional recovery; (6) attenuate cerebral /Ischemia reperfusion injury; (7) inhibit neuronal apoptosis; (8) improve learning and memory; and (9) attenuate neurological deficits (Figs.1-2). [easy_payment currency=”USD”]
Together, this study suggests that Cilostazol may alleviate stroke, and other neurodegenerative diseases (such as multiple sclerosis, cerebral ataxia etc.), promote brain repair, and extend the lifespan of an individual. Thus, pharmacological formulations encompassing “Cilostazol or its analogues, either alone or in combination with other drugs”, may be used to treat stroke and other neurological deficits.
Details of the idea posted:
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Undisclosed mechanistic information: How Cilostazol increases the expression of BDNF and NAMPT and attenuates stroke
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# Research cooperation
Citation: Boominathan, L., Molecular therapy for Stroke: Cilostazol, a phosphodiesterase inhibitor used in the treatment of Perpheral vascular disease, attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits via up regulation of its target genes BDNF and NAMPT, 1/December/2017, 6.44 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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