Site is Being Upgraded

Lifespan extension therapy: Allicin, one of the main components of Garlic, prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 10/January/2017, 11.32 pm

Molecular therapy for Metastatic cancers: Torasemide, an anti-hypertensive drug, increases the expression of tumor/metastatic suppressors GRHL3 and long ncRNA GAS5, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 13/January/2017, 11.20 pm
January 13, 2018
Lifespan extension therapy:  Prostaglandin D2 (PGD2) may increase life span via up-regulation of its target gene BubR1, 13/January/2017, 11.33 pm
January 13, 2018
Show all

Significance of the study:

It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan. 


From research findings to therapeutic opportunity: 

This study suggests, for the first time, that Allicin, by increasing the expression of its target genes,  it may decrease the expression of AT1R.

Figure1. Mechanistic insights into how the lipid-lowering agent Allicin functions as a longevity-promoter. Allicin, by increasing the expression of its downstream target genes, down regulates A1TR expression and promotes longevity.

Figure 2. The chemical structure of Allicin. Allicin may decrease blood pressure, inhibit insulin resistance and attenuate cardiac ageing.

And, thereby, it may: (1) decrease blood pressure; (2) decrease blood sugar levels; (3) inhibit pulmonary fibrosis; (4) enhance bacterial immunity; (5) inhibit myocardial infarction; (6) decelerate ageing process; and (4) extend the lifespan of an individual. Thus, pharmacological formulations encompassing “Allicin or its analogues, either alone or in combination with other anti-ageing/longevity promoting compounds,” may be used to extend the lifespan of an individual (Figures 1-2).

Price 300[easy_payment currency=”USD”]


Details of the research findings: 

Idea Proposed/Formulated by:

Dr L Boominathan Ph.D.  

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How  does Allicin suppress the expression of  angiotensin II type I receptor (AT1R)? 

Amount: $300#

For purchase and payment details, you may reach us at info@genomediscovery.org

#  Research cooperation


References: 

CitationBoominathan, L., Lifespan extension therapy: Allicin, one of the main components of Garlic, prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 10/January/2017, 11.32 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com/

Courtesy: When you cite drop us a line at info@genomediscovery.org

Comments are closed.