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Lifespan extension therapy:  Candesartan, an angiotensin II receptor antagonist used mainly in the treatment of hypertension, may increase life span via up-regulation of its target gene BubR1, 10/January/2017, 7.02 pm

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 What they say: Introduction: 

A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published, in the 1 July  2014 issue of the journal  “EMBO”, by Prof Sinclair, North BJ, and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Lifespan extension therapy:  Candesartan, an angiotensin II receptor antagonist used mainly in the treatment of hypertension, may increase life span via up-regulation of its target gene BubR1


What is known? 

Candesartan has been shown to shown to function as an anti-hypertensive agent. However, the exact mechanism of action is far from clear.


From research findings to therapeutic Opportunity: 

This study suggests, for the first time, that Candesartanby increasing the expression of its target gene, it may: (a) increase the expression of BuBR1; (b) decrease the expression of p70 S6 Kinase; and (c) regulate the expression of a number of longevity-promoting molecules (Fig. 1).

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Figure 1. Candesartan may extend  mammalian life span via up regulation of BuBR1 and down regulation of p70 S6 Kinase

Figure 2. Candesartan may function as a longevity-promoting agent.

 

Thereby, it may: (1) increase insulin sensitivity; (2) attenuate cognitive impairment; (3) delay diseases of aging; (4) slow down cardiac aging; (5) promote resistance to bone, immune and motor dysfunction; (6) promote tissue rejuvenation; and (7) prolong median life span. Thus, pharmacological formulations encompassing “Candesartan or its analogues, either alone or in combination with other drugsat lower doses may be used to extend the lifespan of an individual (fig. 1).


Details on the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Amount: $500#

Undisclosed mechanistic information: How Candesartan  increases the expression of BubR1 and extends mammalian life-span

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

# Research cooperation


References

Web: http://genomediscovery.org or http://newbioideas.com

CitationBoominathan, L., Lifespan extension therapy:  Candesartan, an angiotensin II receptor antagonist used mainly in the treatment of hypertension, may increase life span via up-regulation of its target gene BubR1, 10/January/2017, 7.02 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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